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Substance Name: Midodrine hydrochloride [USAN:USP:JAN]
RN: 43218-56-0
UNII: 59JV96YTXV
InChIKey: MGCQZNBCJBRZDT-UHFFFAOYSA-N

Note

  • An ethanolamine derivative that is an adrenergic alpha-1 agonist. It is used as a vasoconstrictor agent in the treatment of HYPOTENSION.

Molecular Formula

  • C12-H18-N2-O4.Cl-H

Molecular Weight

  • 290.7451
 

Classification Codes

  • Antihypotensive
  • Drug / Therapeutic Agent

Names and Synonyms

Name of Substance

  • Midodrine hydrochloride [USAN:USP:JAN]

Synonyms

  • (+-)-Midodrin hydrochloride
  • (+-)-Midodrine hydrochloride
  • 1-(2',5'-Dimethoxyphenyl)-2-glycinamidoethanol hydrochloride
  • 2-Amino-N-(2-(2,5-dimethoxyphenyl)-2-hyyroxyethyl)acetamide monohydrochloride
  • A 4020 Linz
  • A-4020 Linz
  • Acetamide, 2-amino-N-(beta-hydroxy-2,5-dimethoxyphenethyl)-, hydrochloride
  • Alphamine
  • Amatine
  • EINECS 256-148-3
  • Gutron
  • Hipertan
  • Metligene
  • Midamine
  • Midodrine HCl
  • Midodrine hydrochloride
  • Orvaten
  • ProAmatine
  • St 1085
  • St 1085 [as the base]
  • St. Peter 224
  • TS 701
  • UNII-59JV96YTXV

Systematic Names

  • 2-Amino-N-(2-(2,5-dimethoxyphenyl)-2-hydroxyethyl)acetamide monohydrochloride
  • Acetamide, 2-amino-N-(2-(2,5-dimethoxyphenyl)-2-hydroxyethyl)-, monohydrochloride
  • Acetamide, 2-amino-N-(beta-hydroxy-2,5-dimethoxyphenethyl)-, hydrochloride

Registry Numbers

CAS Registry Number

  • 43218-56-0

FDA UNII

  • 59JV96YTXV

Other Registry Number

  • 3092-17-9

System Generated Number

  • 0043218560

Molecular Formulas

Molecular Formula

  • C12-H18-N2-O4.Cl-H

Molecular Formula Fragments

  • C12-H18-N2-O4
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C12H18N2O4.ClH/c1-17-8-3-4-11(18-2)9(5-8)10(15)7-14-12(16)6-13;/h3-5,10,15H,6-7,13H2,1-2H3,(H,14,16);1H

InChIKey

MGCQZNBCJBRZDT-UHFFFAOYSA-N

Smiles

Cl.COc1ccc(OC)c(c1)C(O)CNC(=O)CN

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 oral 150mg/kg (150mg/kg)   Drugs in Japan Vol. -, Pg. 1333, 1995.
dog LD50 oral 150mg/kg (150mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: ATAXIA
Kiso to Rinsho. Clinical Report. Vol. 21, Pg. 49, 1987.
mouse LD50 intraperitoneal 171mg/kg (171mg/kg)   Drugs in Japan Vol. -, Pg. 1152, 1990.
mouse LD50 intraperitoneal 171mg/kg (171mg/kg) BEHAVIORAL: ATAXIA

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Kiso to Rinsho. Clinical Report. Vol. 21, Pg. 49, 1987.
mouse LD50 intravenous 56200ug/kg (56.2mg/kg)   Drugs in Japan Vol. -, Pg. 1152, 1990.
mouse LD50 intravenous 56200ug/kg (56.2mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: ATAXIA
Kiso to Rinsho. Clinical Report. Vol. 21, Pg. 49, 1987.
mouse LD50 oral 246mg/kg (246mg/kg)   Drugs in Japan Vol. -, Pg. 1152, 1990.
mouse LD50 oral 246mg/kg (246mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: ATAXIA
Kiso to Rinsho. Clinical Report. Vol. 21, Pg. 49, 1987.
mouse LD50 subcutaneous 170mg/kg (170mg/kg)   Drugs in Japan Vol. -, Pg. 1152, 1990.
mouse LD50 subcutaneous 170mg/kg (170mg/kg) BEHAVIORAL: ATAXIA

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Kiso to Rinsho. Clinical Report. Vol. 21, Pg. 49, 1987.
rat LD50 intraperitoneal 31300ug/kg (31.3mg/kg)   Drugs in Japan Vol. -, Pg. 1152, 1990.
rat LD50 intraperitoneal 31300ug/kg (31.3mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: ATAXIA

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Kiso to Rinsho. Clinical Report. Vol. 21, Pg. 49, 1987.
rat LD50 intravenous 18200ug/kg (18.2mg/kg)   Drugs in Japan Vol. -, Pg. 1152, 1990.
rat LD50 intravenous 18200ug/kg (18.2mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: ATAXIA

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Kiso to Rinsho. Clinical Report. Vol. 21, Pg. 49, 1987.
rat LD50 oral 68800ug/kg (68.8mg/kg)   Drugs in Japan Vol. -, Pg. 1152, 1990.
rat LD50 oral 68800ug/kg (68.8mg/kg) BEHAVIORAL: ATAXIA

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Kiso to Rinsho. Clinical Report. Vol. 21, Pg. 49, 1987.
rat LD50 subcutaneous 51mg/kg (51mg/kg)   Drugs in Japan Vol. -, Pg. 1152, 1990.
rat LD50 subcutaneous 51mg/kg (51mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: ATAXIA
Kiso to Rinsho. Clinical Report. Vol. 21, Pg. 49, 1987.
rat LD50 unreported 650ug/kg (0.65mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: TREMOR

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 247, Pg. 217, 1980.