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Substance Name: Formoterol fumarate [USAN:USP:JAN]
RN: 43229-80-7
UNII: P3T5QA5J9N
InChIKey: OBRNDARFFFHCGE-QDSVTUBZSA-N

Classification Codes

  • Bronchodilator
  • Drug / Therapeutic Agent
  • Reproductive Effect

Molecular Formula

  • C19-H24-N2-O4.1/2C4-H4-O4

Molecular Weight

  • 804.8888
 
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Names and Synonyms

Name of Substance

  • Formoterol fumarate (superceded) [USAN]
  • Formoterol fumarate [USAN:USP:JAN]

Synonyms

  • (+-)-2'-Hydroxy-5'-((R*)-1-hydroxy-2-(((R*)-p-methoxy-alpha-methylphenethyl)amino)ethyl)formanilide fumarate (2:1) (salt)
  • Aformoterol
  • Atock
  • BD 40A
  • CGP 25827A
  • Foradil
  • Foradil acrolizer
  • Foradil Aerolizer
  • Foradil Certihaler
  • Formoterol fumarate
  • Formoterol fumarate (superceded)
  • Formoterol fumarate dihydrate
  • Formoterol fumarate inhalation powder
  • NSC 299587
  • Oxis pMDi
  • Performist
  • Perforomist
  • UNII-P3T5QA5J9N
  • YM 08316
  • YM-08316

Systematic Names

  • Formamide, N-(2-hydroxy-5-((1R)-1-hydroxy-2-(((1R)-2-(4-methoxyphenyl)-1-methylethyl)amino)ethyl)phenyl)-, rel-, (E)-2-butenedioate (2:1) (salt)
  • N-(2-Hydroxy-5-(1-hydroxy-2-((2-(4-methoxyphenyl)-1-methylethyl)amino)ethyl)phenyl)formamide, (E)-2-butenedioate (2:1) (salt)

Registry Numbers

CAS Registry Number

  • 43229-80-7

FDA UNII

  • P3T5QA5J9N

Other Registry Numbers

  • 83536-10-1
  • 87481-49-0
  • 87833-61-2

System Generated Number

  • 0043229807

Molecular Formulas

Molecular Formula

  • C19-H24-N2-O4.1/2C4-H4-O4

Molecular Formula Fragments

  • C19-H24-N2-O4
  • C4-H4-O4
  • COMPONENT

Structure Descriptors

InChI

InChI=1S/2C19H24N2O4.C4H4O4/c2*1-13(9-14-3-6-16(25-2)7-4-14)20-11-19(24)15-5-8-18(23)17(10-15)21-12-22;5-3(6)1-2-4(7)8/h2*3-8,10,12-13,19-20,23-24H,9,11H2,1-2H3,(H,21,22);1-2H,(H,5,6)(H,7,8)/b;;2-1+/t2*13-,19+;/m11./s1

InChIKey

OBRNDARFFFHCGE-QDSVTUBZSA-N

Smiles

COc1ccc(C[C@@H](C)NC[C@H](O)c2ccc(O)c(NC=O)c2)cc1.COc3ccc(C[C@@H](C)NC[C@H](O)c4ccc(O)c(NC=O)c4)cc3.OC(=O)\C=C\C(=O)O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 210mg/kg (210mg/kg) LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA

CARDIAC: ARRHYTHMIAS (INCLUDING CHANGES IN CONDUCTION)

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Oyo Yakuri. Pharmacometrics. Vol. 26, Pg. 811, 1983.
mouse LD50 intravenous 71mg/kg (71mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

CARDIAC: ARRHYTHMIAS (INCLUDING CHANGES IN CONDUCTION)

LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA
Oyo Yakuri. Pharmacometrics. Vol. 26, Pg. 811, 1983.
mouse LD50 oral 6700mg/kg (6700mg/kg) LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

CARDIAC: ARRHYTHMIAS (INCLUDING CHANGES IN CONDUCTION)
Oyo Yakuri. Pharmacometrics. Vol. 26, Pg. 811, 1983.
mouse LD50 subcutaneous 640mg/kg (640mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

CARDIAC: ARRHYTHMIAS (INCLUDING CHANGES IN CONDUCTION)

LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA
Oyo Yakuri. Pharmacometrics. Vol. 26, Pg. 811, 1983.
rat LD50 intraperitoneal 170mg/kg (170mg/kg) LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA

CARDIAC: ARRHYTHMIAS (INCLUDING CHANGES IN CONDUCTION)

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Oyo Yakuri. Pharmacometrics. Vol. 26, Pg. 811, 1983.
rat LD50 intravenous 98mg/kg (98mg/kg) LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA

CARDIAC: ARRHYTHMIAS (INCLUDING CHANGES IN CONDUCTION)

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Oyo Yakuri. Pharmacometrics. Vol. 26, Pg. 811, 1983.
rat LD50 oral 3130mg/kg (3130mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA

CARDIAC: ARRHYTHMIAS (INCLUDING CHANGES IN CONDUCTION)
Oyo Yakuri. Pharmacometrics. Vol. 26, Pg. 811, 1983.
rat LD50 subcutaneous 1gm/kg (1000mg/kg) LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA

CARDIAC: ARRHYTHMIAS (INCLUDING CHANGES IN CONDUCTION)

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Oyo Yakuri. Pharmacometrics. Vol. 26, Pg. 811, 1983.