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Substance Name: Trimeprazine tartrate [USP]
RN: 4330-99-8
UNII: 362NW1LD6Z
InChIKey: AJZJIYUOOJLBAU-CEAXSRTFSA-N

Note

  • A phenothiazine derivative that is used as an antipruritic.

Molecular Formula

  • C18-H22-N2-S.1/2C4-H6-O6

Molecular Weight

  • 746.989
 

Classification Codes

  • Antipruritic
  • Drug / Therapeutic Agent
  • Histamine Agents
  • Histamine Antagonists
  • Histamine H1 Antagonists
  • Neurotransmitter Agents
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Names and Synonyms

Name of Substance

  • Trimeprazine tartrate
  • Trimeprazine tartrate [USP]

Synonyms

  • 10-(3-(Dimethylamino)-2-methylpropyl)phenothiazine tartrate (2:1)
  • 10H-Phenothiazine-10-propanamine N,N,beta-trimethyl-, (R-(R*,R*))-2,3-dihydroxybutanedioate (2:1)
  • Alimemazin (RR)-tartrat
  • Alimemazine tartrate
  • Bayer 1219
  • EINECS 224-368-9
  • Nedeltran
  • Panectyl
  • Repeltin
  • RP 6549
  • SKF 5277
  • Temaril
  • Therafene
  • Theralen
  • Theralene
  • Trimeprazine tartrate
  • UNII-362NW1LD6Z
  • Vallergan
  • Vanectyl

Systematic Names

  • 10H-Phenothiazine-10-propanamine N,N,beta-trimethyl-, (R-(R*,R*))-2,3-dihydroxybutanedioate (2:1)
  • Alimemazine tartrate
  • Phenothiazine, 10-(3-(dimethylamino)-2-methylpropyl)-, tartrate (2:1)

Registry Numbers

CAS Registry Number

  • 4330-99-8

FDA UNII

  • 362NW1LD6Z

Other Registry Number

  • 41375-66-0

System Generated Number

  • 0004330998

Molecular Formulas

Molecular Formula

  • C18-H22-N2-S.1/2C4-H6-O6

Molecular Formula Fragments

  • C18-H22-N2-S
  • C4-H6-O6
  • COMPONENT

Structure Descriptors

InChI

1S/2C18H22N2S.C4H6O6/c2*1-14(12-19(2)3)13-20-15-8-4-6-10-17(15)21-18-11-7-5-9-16(18)20;5-1(3(7)8)2(6)4(9)10/h2*4-11,14H,12-13H2,1-3H3;1-2,5-6H,(H,7,8)(H,9,10)/t;;1-,2-/m..1/s1

InChIKey

AJZJIYUOOJLBAU-CEAXSRTFSA-N

Smiles

CC(CN(C)C)CN1c2ccccc2Sc3ccccc13.CC(CN(C)C)CN4c5ccccc5Sc6ccccc46.O[C@H]([C@@H](O)C(=O)O)C(=O)O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 140mg/kg (140mg/kg)   "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 57, 1972.
mouse LD50 intravenous 33mg/kg (33mg/kg)   "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 57, 1972.
mouse LD50 oral 300mg/kg (300mg/kg)   Drugs in Japan Vol. 6, Pg. 41, 1982.
rat LD50 intraperitoneal 110mg/kg (110mg/kg)   "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 57, 1972.
rat LD50 intravenous 35mg/kg (35mg/kg)   "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 57, 1972.
rat LD50 oral 210mg/kg (210mg/kg)   "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 57, 1972.