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Substance Name: Oxitriptan [INN]
RN: 4350-09-8
UNII: C1LJO185Q9
InChIKey: LDCYZAJDBXYCGN-VIFPVBQESA-N

Note

  • The immediate precursor in the biosynthesis of SEROTONIN from tryptophan. It is used as an antiepileptic and antidepressant.

Molecular Formula

  • C11-H12-N2-O3

Molecular Weight

  • 220.2268
 

Classification Codes

  • Antidepressive Agents
  • Antidepressive Agents, Second-Generation
  • Central Nervous System Agents
  • Drug / Therapeutic Agent
  • Psychotropic Drugs
  • Reproductive Effect
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Names and Synonyms

Name of Substance

  • 5-Hydroxytryptophan L-form
  • Oxitriptan [INN]

MeSH Heading

  • 5-Hydroxytryptophan

Synonyms

  • 5-22-14-00278 (Beilstein Handbook Reference)
  • 5-Hydroxy-L-tryptophan
  • BRN 0088200
  • CCRIS 4418
  • Cincofarm
  • EINECS 224-411-1
  • L-5-HTP
  • L-5-Hydroxytryptophan
  • Levothym
  • Oxitriptan
  • Oxitriptano
  • Oxitriptano [INN-Spanish]
  • Oxitriptanum
  • Oxitriptanum [INN-Latin]
  • Oxyfan
  • Pretonine
  • Quietim
  • Serotonyl
  • Telesol
  • Tript-OH
  • Tripten
  • UNII-C1LJO185Q9

Systematic Names

  • 5-Hydroxy-L-tryptophan
  • L-Tryptophan, 5-hydroxy-
  • Oxitriptan
  • Tryptophan, 5-hydroxy-, L-

Registry Numbers

CAS Registry Number

  • 4350-09-8

FDA UNII

  • C1LJO185Q9

Other Registry Numbers

  • 1228817-95-5
  • 34953-84-9

System Generated Number

  • 0004350098

Structure Descriptors

InChI

1S/C11H12N2O3/c12-9(11(15)16)3-6-5-13-10-2-1-7(14)4-8(6)10/h1-2,4-5,9,13-14H,3,12H2,(H,15,16)/t9-/m0/s1

InChIKey

LDCYZAJDBXYCGN-VIFPVBQESA-N

Smiles

c1cc2c(cc1O)c(c[nH]2)C[C@@H](C(=O)O)N

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 298mg/kg (298mg/kg) SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: TREMOR
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 6, Pg. 307, 1975.
mouse LD50 intravenous 375mg/kg (375mg/kg) BEHAVIORAL: ATAXIA

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: EXCITEMENT
Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 69, Pg. 523, 1973.
mouse LD50 oral 1708mg/kg (1708mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: TREMOR

SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 6, Pg. 307, 1975.
mouse LD50 subcutaneous 418mg/kg (418mg/kg) BEHAVIORAL: TREMOR

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 6, Pg. 307, 1975.
rabbit LD50 oral 285mg/kg (285mg/kg) BEHAVIORAL: TREMOR

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 6, Pg. 307, 1975.
rat LD50 intraperitoneal 91mg/kg (91mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: EXCITEMENT

BEHAVIORAL: ATAXIA
Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 69, Pg. 523, 1973.
rat LD50 intravenous 27mg/kg (27mg/kg) SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE

BEHAVIORAL: TREMOR

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 6, Pg. 307, 1975.
rat LD50 oral 243mg/kg (243mg/kg) BEHAVIORAL: ATAXIA

BEHAVIORAL: EXCITEMENT

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 69, Pg. 523, 1973.
rat LD50 subcutaneous 149mg/kg (149mg/kg) SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE

BEHAVIORAL: TREMOR

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 6, Pg. 307, 1975.