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Substance Name: Myfadol hydrochloride
RN: 4370-33-6
UNII: 6HX7RST519
InChIKey: ARCUFWKZXDWDIH-UHFFFAOYSA-N

Classification Code

  • Drug / Therapeutic Agent

Molecular Formula

  • C21-H25-N-O2.Cl-H

Molecular Weight

  • 359.894
 
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Names and Synonyms

Name of Substance

  • Myfadol hydrochloride

Synonyms

  • 1-Phenacyl-2,3-dimethyl-3-(3-hydroxyphenyl)piperidine hydrochloride
  • 2-(3-(m-Hydroxyphenyl)-2,3-dimethylpiperidino)acetophenone hydrochloride
  • m-(1-Benzoylmethyl-2,3-dimethyl-3-piperidyl)phenol hydrochloride
  • TA-306
  • UNII-6HX7RST519

Systematic Names

  • Acetophenone, 2-(3-(m-hydroxyphenyl)-2,3-dimethylpiperidino)-, hydrochloride
  • Ethanone, 2-(3-(3-hydroxyphenyl)-2,3-dimethyl-1-piperidinyl)-1-phenyl-, hydrochloride (9CI)

Registry Numbers

CAS Registry Number

  • 4370-33-6

FDA UNII

  • 6HX7RST519

System Generated Number

  • 0004370336

Molecular Formulas

Molecular Formula

  • C21-H25-N-O2.Cl-H

Molecular Formula Fragments

  • C21-H25-N-O2
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C21H25NO2.ClH/c1-16-21(2,18-10-6-11-19(23)14-18)12-7-13-22(16)15-20(24)17-8-4-3-5-9-17;/h3-6,8-11,14,16,23H,7,12-13,15H2,1-2H3;1H

InChIKey

ARCUFWKZXDWDIH-UHFFFAOYSA-N

Smiles

c1([C@@]2([C@@H]([N@@](CC(c3ccccc3)=O)CCC2)C)C)cc(ccc1)O.Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 234mg/kg (234mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: EXCITEMENT

BEHAVIORAL: TREMOR
Japanese Journal of Pharmacology. Vol. 18, Pg. 406, 1968.
mouse LD50 intravenous 117mg/kg (117mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: TREMOR
Japanese Journal of Pharmacology. Vol. 18, Pg. 406, 1968.
mouse LD50 oral > 800mg/kg (800mg/kg)   Japanese Journal of Pharmacology. Vol. 18, Pg. 406, 1968.
mouse LD50 subcutaneous > 800mg/kg (800mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Japanese Journal of Pharmacology. Vol. 18, Pg. 406, 1968.