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Substance Name: Chlordiazepoxide hydrochloride [USAN:USP:BAN:JAN]
RN: 438-41-5
UNII: MFM6K1XWDK
InChIKey: DMLFJMQTNDSRFU-UHFFFAOYSA-N

Note

  • An anxiolytic benzodiazepine derivative with anticonvulsant, sedative, and amnesic properties. It has also been used in the symptomatic treatment of alcohol withdrawal.

Molecular Formula

  • C16-H14-Cl-N3-O.Cl-H

Molecular Weight

  • 336.2205
 

Classification Codes

Classification Codes

  • Drug / Therapeutic Agent
  • Human Data
  • Mutation Data
  • Reproductive Effect
  • Sedative-Hypnotic

Superlist Classification Code

  • DEA Schedule IV

Names and Synonyms

Name of Substance

  • Chlordiazepoxide hydrochloride [USAN:USP:BAN:JAN]

Synonyms

  • 3H-1,4-Benzodiazepin-2-amine, 7-chloro-N-methyl-5-phenyl-, 4-oxide, monohydrochloride
  • 7-Chloro-2-(methylamino)-5-phenyl-3H-1,4-benzodiazepine 4-oxide monohydrochloride
  • A-Poxide
  • Ansiacal
  • Benzodiapin
  • Calmoden
  • Cebrum
  • Chlordiazachel
  • Chlordiazepoksid
  • Chlordiazepoxide HCl
  • Chlordiazepoxide hydrochloride
  • Chlordiazepoxide monohydrochloride
  • Chlorodiazepoxide hydrochloride
  • Clopoxide chloride
  • Contol
  • Diazachel (Obs.)
  • Droxol hydrochloride
  • EINECS 207-117-8
  • Equibral
  • J-Liberty
  • Labican
  • Lentotran
  • Libritabs hydrochloride
  • Librium
  • Librium hydrochloride
  • Lygen
  • Methaminodiazepoxide hydrochloride
  • Murcil
  • Napoton hydrochloride
  • Novosed
  • NSC 115748
  • Protensin
  • Psichial
  • Reliberan
  • Retcol
  • Risachief hydrochloride
  • Ro 5-0690
  • Seren vita
  • Sophiamin
  • Tensinyl
  • Timosin
  • Trakipeal
  • UNII-MFM6K1XWDK
  • Viansin

Systematic Names

  • 3H-1,4-Benzodiazepin-2-amine, 7-chloro-N-methyl-5-phenyl-, 4-oxide, monohydrochloride
  • 3H-1,4-Benzodiazepine, 7-chloro-2-methylamino-5-phenyl-, 4-oxide, monohydrochloride
  • Chlordiazepoxide hydrochloride

Superlist Names

  • Chlordiazepoxide hydrochloride
  • DEA No. 2744
  • sk-Lygen

Mixture Name

  • Librax

Registry Numbers

CAS Registry Number

  • 438-41-5

FDA UNII

  • MFM6K1XWDK

Related Registry Number

  • 58-25-3

System Generated Number

  • 0000438415

Molecular Formulas

Molecular Formula

  • C16-H14-Cl-N3-O.Cl-H

Molecular Formula Fragments

  • C16-H14-Cl-N3-O
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

InChI=1S/C16H14ClN3O.ClH/c1-18-15-10-20(21)16(11-5-3-2-4-6-11)13-9-12(17)7-8-14(13)19-15;/h2-9H,10H2,1H3,(H,18,19);1H

InChIKey

DMLFJMQTNDSRFU-UHFFFAOYSA-N

Smiles

Cl.CNC1=Nc2ccc(Cl)cc2C(=[N+]([O-])C1)c3ccccc3

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 oral 1gm/kg (1000mg/kg)   "Drug Dosages in Laboratory Animals - A Handbook," Rev. ed., Barnes, C.D., and L.G. Eltherington, Berkeley, Univ. of California Press, 1973Vol. -, Pg. 71, 1973.
man TDLo oral 39mg/kg/30D-I (39mg/kg) BRAIN AND COVERINGS: CHANGES IN SURFACE EEG

BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS"

BEHAVIORAL: ATAXIA
Clinical Toxicology. Vol. 2, Pg. 5, 1969.
mouse LD50 intraperitoneal 200mg/kg (200mg/kg)   Journal of Medicinal Chemistry. Vol. 14, Pg. 1106, 1971.
mouse LD50 intravenous 95mg/kg (95mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: MUSCLE WEAKNESS

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Journal of Pharmacology and Experimental Therapeutics. Vol. 129, Pg. 163, 1960.
mouse LD50 oral 530mg/kg (530mg/kg)   "Benzodinzenines," Garattini, S., et al., New York, Raven Press, 1973Vol. -, Pg. 39, 1973.
mouse LD50 parenteral 700mg/kg (700mg/kg)   United States Patent Document. Vol. #4371536,
mouse LD50 subcutaneous 530mg/kg (530mg/kg)   "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 159, 1972.
quail LD50 oral 1gm/kg (1000mg/kg)   Archives of Environmental Contamination and Toxicology. Vol. 12, Pg. 355, 1983.
rabbit LD50 intravenous 36mg/kg (36mg/kg) BEHAVIORAL: REGIDITY

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE
International Journal of Neuropharmacology. Vol. 5, Pg. 305, 1966.
rabbit LD50 oral 590mg/kg (590mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 178, Pg. 216, 1969.
rat LD50 intraperitoneal 276mg/kg (276mg/kg)   Toxicology and Applied Pharmacology. Vol. 16, Pg. 556, 1970.
rat LD50 intravenous 165mg/kg (165mg/kg)   "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 159, 1972.
rat LD50 oral 537mg/kg (537mg/kg)   Toxicology and Applied Pharmacology. Vol. 16, Pg. 556, 1970.
rat LD50 subcutaneous 800mg/kg (800mg/kg)   "Drug Dosages in Laboratory Animals - A Handbook," Rev. ed., Barnes, C.D., and L.G. Eltherington, Berkeley, Univ. of California Press, 1973Vol. -, Pg. 71, 1973.
women TDLo oral 8400ug/kg/2W- (8.4mg/kg) BEHAVIORAL: ATAXIA

BRAIN AND COVERINGS: CHANGES IN SURFACE EEG

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Clinical Toxicology. Vol. 2, Pg. 5, 1969.