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Substance Name: Protriptyline [INN:BAN]
RN: 438-60-8
UNII: 4NDU154T12
InChIKey: BWPIARFWQZKAIA-UHFFFAOYSA-N

Note

  • Tricyclic antidepressant similar in action and side effects to IMIPRAMINE. It may produce excitation.

Molecular Formula

  • C19-H21-N

Molecular Weight

  • 263.3819
 

Classification Codes

  • Adrenergic Agents
  • Adrenergic Uptake Inhibitors
  • Antidepressive Agents
  • Antidepressive Agents, Tricyclic
  • Central Nervous System Agents
  • Drug / Therapeutic Agent
  • Membrane Transport Modulators
  • Neurotransmitter Agents
  • Neurotransmitter Uptake Inhibitors
  • Psychotropic Drugs

Names and Synonyms

Results Name

  • Protriptyline [INN:BAN]

Name of Substance

  • Protriptyline
  • Protriptyline [INN:BAN]

MeSH Heading

  • Protriptyline

Synonyms

  • 5-(3-Methylaminopropyl)-5H-dibenzo(a,d)cycloheptene
  • 5H-Dibenzo(a,d)cycloheptene-5-propanamine, N-methyl-
  • 5H-Dibenzo(a,d)cycloheptene-5-propylamine, N-methyl-
  • 7-(3-Methylaminopropyl)-1,2:5,6-dibenzocycloheptatriene
  • Amimetilina
  • BRN 2217411
  • EINECS 207-119-9
  • HSDB 3391
  • N-3-(5H-Dibenzo(a,d)cyclohepten-5-yl)propyl-N-methylamine
  • N-Methyl-5H-dibenzo(a,d)cycloheptene-5-propylamine
  • Protriptilina
  • Protriptilina [INN-Spanish]
  • Protriptyline
  • Protriptylinum
  • Protriptylinum [INN-Latin]
  • Protryptyline
  • Triptil
  • UNII-4NDU154T12

Systematic Names

  • 5H-Dibenzo(a,d)cycloheptene-5-propanamine, N-methyl-
  • 5H-Dibenzo(a,d)cycloheptene-5-propylamine, N-methyl-
  • Protriptyline

Registry Numbers

CAS Registry Number

  • 438-60-8

FDA UNII

  • 4NDU154T12

Related Registry Number

  • 1225-55-4 (hydrochloride)

System Generated Number

  • 0000438608

Structure Descriptors

InChI

1S/C19H21N/c1-20-14-6-11-19-17-9-4-2-7-15(17)12-13-16-8-3-5-10-18(16)19/h2-5,7-10,12-13,19-20H,6,11,14H2,1H3

InChIKey

BWPIARFWQZKAIA-UHFFFAOYSA-N

Smiles

CNCCCC1c2ccccc2C=Cc3c1cccc3

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 67mg/kg (67mg/kg)   Farmaco, Edizione Pratica. Vol. 25, Pg. 519, 1970.
mouse LD50 intravenous 30mg/kg (30mg/kg) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) Journal of Medicinal Chemistry. Vol. 17, Pg. 65, 1974.
mouse LD50 oral 269mg/kg (269mg/kg)   Farmaco, Edizione Pratica. Vol. 25, Pg. 519, 1970.
mouse LD50 subcutaneous 192mg/kg (192mg/kg)   Farmaco, Edizione Pratica. Vol. 25, Pg. 519, 1970.
rabbit LD50 intravenous 8200mg/kg (8200mg/kg)   Farmaco, Edizione Pratica. Vol. 25, Pg. 519, 1970.
rabbit LD50 oral 310mg/kg (310mg/kg)   Farmaco, Edizione Pratica. Vol. 25, Pg. 519, 1970.
rat LD50 intraperitoneal 42mg/kg (42mg/kg)   Farmaco, Edizione Pratica. Vol. 25, Pg. 519, 1970.
rat LD50 oral 240mg/kg (240mg/kg)   Farmaco, Edizione Pratica. Vol. 25, Pg. 519, 1970.

Physical Properties

Physical Property Value Units Temp (deg C) Source
log P (octanol-water) 4.890 (none)   EST
Water Solubility 1.040 mg/L 25 EST
Vapor Pressure 2.59E-06 mm Hg 25 EST
Henry's Law Constant 2.64E-08 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 1.45E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.