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Substance Name: Niflumic acid [INN:BAN:DCF]
RN: 4394-00-7
UNII: 4U5MP5IUD8
InChIKey: JZFPYUNJRRFVQU-UHFFFAOYSA-N

Note

  • An analgesic and anti-inflammatory agent used in the treatment of rheumatoid arthritis.

Molecular Formula

  • C13-H9-F3-N2-O2

Molecular Weight

  • 282.2201
 

Classification Codes

  • Analgesics
  • Analgesics, Non-Narcotic
  • Anti-Inflammatory Agents
  • Anti-Inflammatory Agents, Non-Steroidal
  • Antirheumatic Agents
  • Cyclooxygenase Inhibitors
  • Drug / Therapeutic Agent
  • Enzyme Inhibitors
  • Peripheral Nervous System Agents
  • Reproductive Effect
  • Sensory System Agents
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Names and Synonyms

Name of Substance

  • Niflumic acid
  • Niflumic acid [INN:BAN:DCF]

MeSH Heading

  • Niflumic acid

Synonyms

  • 2-(3-(Trifluoromethyl)-phenyl)aminonicotinic acid
  • 2-(3-(Trifluoromethyl)anilino)nicotinic acid
  • 5-22-13-00598 (Beilstein Handbook Reference)
  • Acide niflumique
  • Acide niflumique [French]
  • Acide niflumique [INN-French]
  • Acido niflumico
  • Acido niflumico [INN-Spanish]
  • Acido niflumico [Italian]
  • Acidum niflumicum
  • Acidum niflumicum [INN-Latin]
  • Actol
  • Aza-2 dimethyl-2',3' (tetrazolyl-5)-6 diphenylamino
  • Aza-2 dimethyl-2',3' (tetrazolyl-5)-6 diphenylamino [French]
  • BRN 0489360
  • CCRIS 5740
  • EINECS 224-516-2
  • Forenol
  • Landruma
  • Niflumic acid
  • Nifluril
  • NSC 758196
  • SC 1332
  • UNII-4U5MP5IUD8
  • UP 83

Systematic Names

  • 2-(3-(Trifluoromethyl)anilino)nicotinic acid
  • 3-Pyridinecarboxylic acid, 2-((3-(trifluoromethyl)phenyl)amino)-
  • Nicotinic acid, 2-(alpha,alpha,alpha-trifluoro-m-toluidino)-
  • Niflumic acid

Registry Numbers

CAS Registry Number

  • 4394-00-7

FDA UNII

  • 4U5MP5IUD8

System Generated Number

  • 0004394007

Structure Descriptors

InChI

InChI=1S/C13H9F3N2O2/c14-13(15,16)8-3-1-4-9(7-8)18-11-10(12(19)20)5-2-6-17-11/h1-7H,(H,17,18)(H,19,20)

InChIKey

JZFPYUNJRRFVQU-UHFFFAOYSA-N

Smiles

OC(=O)c1cccnc1Nc2cccc(c2)C(F)(F)F

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
guinea pig LD50 intravenous 174mg/kg (174mg/kg)   United States Patent Document. Vol. #3466373,
mouse LD50 intraperitoneal 196mg/kg (196mg/kg)   Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 68, Pg. 683, 1972.
mouse LD50 intravenous 152mg/kg (152mg/kg)   Therapie. Vol. 22, Pg. 157, 1967.
mouse LD50 oral 350mg/kg (350mg/kg)   United States Patent Document. Vol. #4122202,
rat LD50 intraperitoneal 100mg/kg (100mg/kg)   United States Patent Document. Vol. #3466373,
rat LD50 oral 250mg/kg (250mg/kg) BEHAVIORAL: ANALGESIA Journal of Medicinal Chemistry. Vol. 16, Pg. 780, 1973.

Physical Properties

Physical Property Value Units Temp (deg C) Source
log P (octanol-water) 4.43 (none)   EXP
Water Solubility 19 mg/L 25 EXP
Vapor Pressure 9.92E-07 mm Hg 25 EST
Henry's Law Constant 2.40E-13 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 3.30E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.