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Substance Name: Niflumic acid [INN:BAN:DCF]
RN: 4394-00-7
UNII: 4U5MP5IUD8
InChIKey: JZFPYUNJRRFVQU-UHFFFAOYSA-N
Note
- An analgesic and anti-inflammatory agent used in the treatment of rheumatoid arthritis.
Molecular Formula
- C13-H9-F3-N2-O2
Molecular Weight
- 282.2201
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- Classifications
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- Registry Numbers
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- Toxicity
- Physical Properties
Classification Codes
- Analgesics
- Analgesics, Non-Narcotic
- Anti-Inflammatory Agents
- Anti-Inflammatory Agents, Non-Steroidal
- Antirheumatic Agents
- Cyclooxygenase Inhibitors
- Drug / Therapeutic Agent
- Enzyme Inhibitors
- Peripheral Nervous System Agents
- Reproductive Effect
- Sensory System Agents
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Names and Synonyms
Name of Substance
- Niflumic acid
- Niflumic acid [INN:BAN:DCF]
MeSH Heading
- Niflumic acid
Synonyms
- 2-(3-(Trifluoromethyl)-phenyl)aminonicotinic acid
- 2-(3-(Trifluoromethyl)anilino)nicotinic acid
- 5-22-13-00598 (Beilstein Handbook Reference)
- Acide niflumique
- Acide niflumique [French]
- Acide niflumique [INN-French]
- Acido niflumico
- Acido niflumico [INN-Spanish]
- Acido niflumico [Italian]
- Acidum niflumicum
- Acidum niflumicum [INN-Latin]
- Actol
- Aza-2 dimethyl-2',3' (tetrazolyl-5)-6 diphenylamino
- Aza-2 dimethyl-2',3' (tetrazolyl-5)-6 diphenylamino [French]
- BRN 0489360
- CCRIS 5740
- EINECS 224-516-2
- Forenol
- Landruma
- Niflumic acid
- Nifluril
- SC 1332
- UNII-4U5MP5IUD8
- UP 83
Systematic Names
- 2-(3-(Trifluoromethyl)anilino)nicotinic acid
- 3-Pyridinecarboxylic acid, 2-((3-(trifluoromethyl)phenyl)amino)-
- Nicotinic acid, 2-(alpha,alpha,alpha-trifluoro-m-toluidino)-
- Niflumic acid
Registry Numbers
CAS Registry Number
- 4394-00-7
FDA UNII
- 4U5MP5IUD8
System Generated Number
- 0004394007
Structure Descriptors
InChI
1S/C13H9F3N2O2/c14-13(15,16)8-3-1-4-9(7-8)18-11-10(12(19)20)5-2-6-17-11/h1-7H,(H,17,18)(H,19,20)InChIKey
JZFPYUNJRRFVQU-UHFFFAOYSA-NSmiles
c1(c(cccn1)Toxicity
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| guinea pig | LD50 | intravenous | 174mg/kg (174mg/kg) | United States Patent Document. Vol. #3466373, | |
| mouse | LD50 | intraperitoneal | 196mg/kg (196mg/kg) | Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 68, Pg. 683, 1972. | |
| mouse | LD50 | intravenous | 152mg/kg (152mg/kg) | Therapie. Vol. 22, Pg. 157, 1967. | |
| mouse | LD50 | oral | 350mg/kg (350mg/kg) | United States Patent Document. Vol. #4122202, | |
| rat | LD50 | intraperitoneal | 100mg/kg (100mg/kg) | United States Patent Document. Vol. #3466373, | |
| rat | LD50 | oral | 250mg/kg (250mg/kg) | BEHAVIORAL: ANALGESIA | Journal of Medicinal Chemistry. Vol. 16, Pg. 780, 1973. |
Physical Properties
| Physical Property | Value | Units | Temp (deg C) | Source |
|---|---|---|---|---|
| log P (octanol-water) | 4.43 | (none) | EXP | |
| Water Solubility | 19 | mg/L | 25 | EXP |
| Vapor Pressure | 9.92E-07 | mm Hg | 25 | EST |
| Henry's Law Constant | 2.40E-13 | atm-m3/mole | 25 | EST |
| Atmospheric OH Rate Constant | 3.30E-11 | cm3/molecule-sec | 25 | EST |
Physical property data is provided to ChemIDplus by SRC, Inc.