Skip Navigation
ChemIDplus A TOXNET DATABASE LiteBrowseAdvanced

Substance Name: Ajmaline hydrochloride
RN: 4410-48-4
UNII: 140MW6WGAF
InChIKey: FNCWZVOLGCRECX-LCJCZRDQSA-N

Note

  • An alkaloid found in the root of Rauwolfia serpentina, among other plant sources. It is a class Ia antiarrhythmic agent that apparently acts by changing the shape and threshold of cardiac action potentials.

Molecular Formula

  • C20-H26-N2-O2.x-Cl-H

Molecular Weight

  • 362.8983
 
* denotes mobile formatted website

Links to Resources

NLM Resources (File Locators)

Other Resources (Internet Locators)


Search for this InChIKey on the Web

Names and Synonyms

Name of Substance

  • Ajmaline hydrochloride

Synonyms

  • Chlorhydrate de raugalline
  • Chlorhydrate de raugalline [French]
  • EINECS 224-562-3
  • UNII-140MW6WGAF

Systematic Names

  • Ajmalan-17(R),21alpha-diol hydrochloride
  • Ajmalan-17,20-diol, hydrochloride, (17R,21alpha)-
  • Ajmaline, hydrochloride

Registry Numbers

CAS Registry Number

  • 4410-48-4

FDA UNII

  • 140MW6WGAF

System Generated Number

  • 0004410484

Molecular Formulas

Molecular Formula

  • C20-H26-N2-O2.x-Cl-H

Molecular Formula Fragments

  • C20-H26-N2-O2
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C20H26N2O2.ClH/c1-3-10-11-8-14-17-20(12-6-4-5-7-13(12)21(17)2)9-15(16(11)18(20)23)22(14)19(10)24;/h4-7,10-11,14-19,23-24H,3,8-9H2,1-2H3;1H/t10-,11-,14-,15-,16-,17-,18+,19+,20+;/m0./s1

InChIKey

FNCWZVOLGCRECX-LCJCZRDQSA-N

Smiles

Cl.CC[C@H]1[C@@H]2C[C@H]3[C@@H]4N(C)c5ccccc5[C@]46C[C@@H]([C@H]2[C@H]6O)N3[C@@H]1O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
cat LDLo intravenous 2mg/kg (2mg/kg) CARDIAC: PULSE RATE

CARDIAC: ARRHYTHMIAS (INCLUDING CHANGES IN CONDUCTION)
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 216, Pg. 63, 1975.
dog LDLo intravenous 20400ug/kg (20.4mg/kg)   Journal de Pharmacologie. Vol. 2, Pg. 240, 1971.
guinea pig LD50 oral 135mg/kg (135mg/kg)   Farmaco, Edizione Pratica. Vol. 35, Pg. 49, 1980.
guinea pig LDLo intravenous 27700ug/kg (27.7mg/kg)   Farmaco, Edizione Pratica. Vol. 35, Pg. 49, 1980.
mouse LD50 intraperitoneal 105mg/kg (105mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Archives Internationales de Pharmacodynamie et de Therapie. Vol. 127, Pg. 163, 1960.
mouse LD50 intravenous 26mg/kg (26mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Archives Internationales de Pharmacodynamie et de Therapie. Vol. 127, Pg. 163, 1960.
mouse LD50 oral 205mg/kg (205mg/kg)   Farmaco, Edizione Pratica. Vol. 35, Pg. 49, 1980.
rabbit LDLo intravenous 15100ug/kg (15.1mg/kg)   Farmaco, Edizione Pratica. Vol. 35, Pg. 49, 1980.
rat LD50 intraperitoneal 86mg/kg (86mg/kg) AUTONOMIC NERVOUS SYSTEM: "SMOOTH MUSCLE RELAXANT (MECHANISM UNDEFINED, SPASMOLYTIC)"

BEHAVIORAL: ATAXIA
Farmaco, Edizione Pratica. Vol. 35, Pg. 49, 1980.
rat LD50 intravenous 19300ug/kg (19.3mg/kg) AUTONOMIC NERVOUS SYSTEM: "SMOOTH MUSCLE RELAXANT (MECHANISM UNDEFINED, SPASMOLYTIC)"

BEHAVIORAL: ATAXIA
Farmaco, Edizione Pratica. Vol. 35, Pg. 49, 1980.
rat LD50 oral 290mg/kg (290mg/kg) BEHAVIORAL: ATAXIA

AUTONOMIC NERVOUS SYSTEM: "SMOOTH MUSCLE RELAXANT (MECHANISM UNDEFINED, SPASMOLYTIC)"
Farmaco, Edizione Pratica. Vol. 35, Pg. 49, 1980.