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Substance Name: Eribulin mesylate [USAN]
RN: 441045-17-6
UNII: AV9U0660CW
InChIKey: QAMYWGZHLCQOOJ-WRNBYXCMSA-N
Note
- A halichondrin B derivative that suppresses microtubule growth and acts as an antimitotic agent.
NCI: The mesylate salt of a synthetic analogue of halichondrin B, a substance derived from a marine sponge (Lissodendoryx sp.) with antineoplastic activity. Eribulin binds to the vinca domain of tubulin and inhibits the polymerization of tubulin and the assembly of microtubules, resulting in inhibition of mitotic spindle assembly, induction of cell cycle arrest at G2/M phase, and, potentially, tumor regression. (NCI Thesaurus)
Molecular Formula
- C40-H59-N-O11.C-H4-O3-S
Molecular Weight
- 826.0077
Classification Codes
- Antineoplastic
- Antineoplastic Agents
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Names and Synonyms
Name of Substance
- Eribulin mesylate [USAN]
Synonyms
- (2R,3R,3aS,7R,8aS,9S,10aR,11S,12R,13aR,13bS,15S,18S,21S,24S,26R,28R,29aS)-2-((2S)-3-amino-2-hydroxypropyl)-3-methoxy-26-methyl-20,27-dimethylidenehexacosahydro-11,15:18,21:24,28-triepoxy-7,9-ethano-12,15-methano-9H,15H-furo(3,2-i)furo(2',3':5,6)pyrano(4,3-b)(1,4)dioxacyclopentacosin-5(4H)-one methanesulfonate (salt)
- E 7389
- E7389
- Eribulin mesylate
- Halaven
- UNII-AV9U0660CW
Systematic Name
- 11,15:18,21:24,28-Triepoxy-7,9-ethano-12,15-methano-9H,15H-furo(3,2-i)furo(2',3':5,6)pyrano(4,3-b)(1,4)dioxacyclopentacosin-5(4H)-one, 2-((2S)-3- amino-2-hydroxypropyl)hexacosahydro-3-methoxy-26-methyl-20,27-bis(methylene)-, 2R,3R,3aS,7R,8aS,9S,10aR,11S,12R,13aR,13bS,15S,18S,21S,24S,26R,28R,29aS)-, methanesulfonate (salt)
Registry Numbers
CAS Registry Number
- 441045-17-6
FDA UNII
- AV9U0660CW
System Generated Number
- 0441045176