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Substance Name: Atropine Oxide [INN]
RN: 4438-22-6
UNII: 3Y03IC177D
InChIKey: HGWPFSBHDACWNL-LZYIFBDPSA-N

Molecular Formula

  • C17-H23-N-O4

Molecular Weight

  • 305.3717
 
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Names and Synonyms

Results Name

  • Atropine Oxide [INN]

Name of Substance

  • Atropine N-oxide
  • Atropine Oxide [INN]

Synonyms

  • 8-Azabicyclo(3.2.1)octan-3alpha-ol, 8-methyl-, 8-oxide, tropate
  • Aminoxytropine tropate
  • Atropina ossida
  • Atropina ossida [DCIT]
  • Atropine N-oxide
  • Atropine oxide
  • Atropine-oxyde
  • Atropine-oxyde [INN-French]
  • Atropini oxidum
  • Atropini oxydum
  • Atropini oxydum [INN-Latin]
  • Genatropin
  • Genatropine
  • NSC 72861
  • Oxido de atropina
  • Oxido de atropina [INN-Spanish]
  • UNII-3Y03IC177D
  • Xtro, base

Systematic Names

  • 1-alpha-H,5-alpha-H-Tropan-3-alpha-ol, (+-)-tropate (ester), 8-oxide
  • 1alphaH,5alphaH-Tropan-3alpha-ol (+-)-tropate (ester), 8-oxide
  • Benzeneacetic acid, alpha-(hydroxymethyl)-, 8-methyl-8-azabicyclo(3.2.1)oct-3-yl ester, endo-(+-)-, N-oxide
  • Benzeneacetic acid, alpha-(hydroxymethyl)-, 8-methyl-8-oxido-8-azabicyclo(3.2.1)oct-3-yl ester, endo-

Registry Numbers

CAS Registry Number

  • 4438-22-6

FDA UNII

  • 3Y03IC177D

System Generated Number

  • 0004438226

Structure Descriptors

InChI

InChI=1S/C17H23NO4/c1-18(21)13-7-8-14(18)10-15(9-13)22-17(20)16(11-19)12-5-3-2-4-6-12/h2-6,13-16,19H,7-11H2,1H3/t13-,14+,15+,16?,18?

InChIKey

HGWPFSBHDACWNL-LZYIFBDPSA-N

Smiles

C[N+]1([O-])[C@@H]2CC[C@H]1C[C@H](C2)OC(=O)C(CO)c3ccccc3

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LDLo unreported 225mg/kg (225mg/kg)   "Structure et Activite Pharmacodyanmique des Medicaments du Systeme Nerveux Vegetatif," Bovet, D., and F. Bovet-Nitti, New York, S. Karger, 1948Vol. -, Pg. 513, 1948.
mouse LD50 subcutaneous 1gm/kg (1000mg/kg)   "Vergleichende Untersuchungen uber Genatropin und Atropin, Dissertation," Rathscheck, U., Pharmakologischen Institut der Westfalichen Wilhelms-Universitat Muenster/Westf., Fed. Rep. Ger., 1934Vol. -, Pg. -, 1934.