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Substance Name: Vandetanib [USAN:INN:BAN:JAN]
RN: 443913-73-3
UNII: YO460OQ37K
InChIKey: UHTHHESEBZOYNR-UHFFFAOYSA-N

Note

  • A VEGF receptor tyrosine kinase inhibitor.

Classification Codes

  • Antineoplastic
  • Treatment of Non-Small Cell Lung Cancer and Other Solid Tumors

Molecular Formula

  • C22-H24-Br-F-N4-O2

Molecular Weight

  • 475.3596
 

Names and Synonyms

Name of Substance

  • Vandetanib [USAN:INN:BAN:JAN]

Synonyms

  • Caprelsa
  • HSDB 8198
  • N-(4-Bromo-2-fluorophenyl)-6-methoxy-7-((1-methyl-4-piperidinyl)methoxy)-4-quinazolinamine
  • N-(4-Bromo-2-fluorophenyl)-6-methoxy-7-((1-methylpiperidin-4-yl)methoxy)quinazolin-4-amine
  • UNII-YO460OQ37K
  • Vandetanib
  • Zactima
  • ZD 6474
  • ZD6474

Systematic Name

  • 4-Quninazolinamine, N-(4-bromo-2-fluorophenyl)-6-methoxy-7-((1-methyl-4-piperidinyl)methoxy)-

Registry Numbers

CAS Registry Number

  • 443913-73-3

FDA UNII

  • YO460OQ37K

Other Registry Number

  • 338992-00-0

System Generated Number

  • 0443913733

Structure Descriptors

InChI

1S/C22H24BrFN4O2/c1-28-7-5-14(6-8-28)12-30-21-11-19-16(10-20(21)29-2)22(26-13-25-19)27-18-4-3-15(23)9-17(18)24/h3-4,9-11,13-14H,5-8,12H2,1-2H3,(H,25,26,27)

InChIKey

UHTHHESEBZOYNR-UHFFFAOYSA-N

Smiles

COc1cc2c(Nc3ccc(Br)cc3F)ncnc2cc1OCC4CCN(C)CC4