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Substance Name: Pazopanib [INN:BAN]
RN: 444731-52-6
UNII: 7RN5DR86CK
InChIKey: CUIHSIWYWATEQL-UHFFFAOYSA-N

Notes

  • A protein kinase inhibitor.
  • NCI: The hydrochloride salt of a small molecule inhibitor of multiple protein tyrosine kinases with potential antineoplastic activity. Pazopanib selectively inhibits vascular endothelial growth factor receptors (VEGFR)-1, -2 and -3, c-kit and platelet derived growth factor receptor (PDGF-R), which may result in inhibition of angiogenesis in tumors in which these receptors are upregulated. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)

Molecular Formula

  • C21-H23-N7-O2-S

Molecular Weight

  • 437.5257
 

Names and Synonyms

Name of Substance

  • Pazopanib [INN:BAN]

Synonyms

  • GW7 86034
  • GW786034
  • HSDB 8210
  • Pazopanib
  • UNII-7RN5DR86CK
  • Votrient

Systematic Name

  • Benzenesulfonamide, 5-((4-((2,3-dimethyl-2H-indazol-6-yl)methylamino)-2-pyrimidinyl)amino)-2-methyl-

Registry Numbers

CAS Registry Number

  • 444731-52-6

FDA UNII

  • 7RN5DR86CK

Other Registry Number

  • 790713-33-6

System Generated Number

  • 0444731526

Structure Descriptors

InChI

1S/C21H23N7O2S/c1-13-5-6-15(11-19(13)31(22,29)30)24-21-23-10-9-20(25-21)27(3)16-7-8-17-14(2)28(4)26-18(17)12-16/h5-12H,1-4H3,(H2,22,29,30)(H,23,24,25)

InChIKey

CUIHSIWYWATEQL-UHFFFAOYSA-N

Smiles

Cc1ccc(cc1S(=O)(=O)N)Nc2nccc(n2)N(C)c3ccc4c(n(nc4c3)C)C