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Substance Name: Methyl fluoroacetate
RN: 453-18-9
UNII: MO8U9H1FAS
InChIKey: RJBYSQHLLIHSLT-UHFFFAOYSA-N

Classification Codes

  • Agricultural Chemical
  • Human Data
  • Rodenticide

Molecular Formula

  • C3-H5-F-O2

Molecular Weight

  • 92.0685
 
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Names and Synonyms

Name of Substance

  • Methyl fluoroacetate

Synonyms

  • 4-02-00-00447 (Beilstein Handbook Reference)
  • BRN 1740631
  • EINECS 207-218-7
  • Fluoroacetic acid, methyl ester
  • Methyl fluoroacetate
  • Methylester kyseliny fluoroctove
  • Methylester kyseliny fluoroctove [Czech]
  • TL 551
  • UNII-MO8U9H1FAS

Systematic Names

  • Acetic acid, fluoro-, methyl ester
  • Methyl fluoroacetate

Superlist Name

  • Methyl fluoroacetate

Registry Numbers

CAS Registry Number

  • 453-18-9

FDA UNII

  • MO8U9H1FAS

System Generated Number

  • 0000453189

Structure Descriptors

InChI

1S/C3H5FO2/c1-6-3(5)2-4/h2H2,1H3

InChIKey

RJBYSQHLLIHSLT-UHFFFAOYSA-N

Smiles

COC(=O)CF

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
cat LC50 inhalation 25mg/m3/10M (25mg/m3) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

CARDIAC: ARRHYTHMIAS (INCLUDING CHANGES IN CONDUCTION)

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
National Technical Information Service. Vol. PB158-508,
cat LD50 intravenous 200ug/kg (0.2mg/kg) CARDIAC: ARRHYTHMIAS (INCLUDING CHANGES IN CONDUCTION)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
National Technical Information Service. Vol. PB158-508,
cat LD50 oral 300ug/kg (0.3mg/kg) GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION

BEHAVIORAL: COMA
National Technical Information Service. Vol. PB158-508,
cat LD50 subcutaneous 300ug/kg (0.3mg/kg) BEHAVIORAL: COMA

GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION
National Technical Information Service. Vol. PB158-508,
chicken LDLo intravenous 15mg/kg (15mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 87, Pg. 90, 1946.
dog LC50 inhalation 25mg/m3/10M (25mg/m3) GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION

BEHAVIORAL: COMA
National Technical Information Service. Vol. PB158-508,
dog LD50 intravenous 60ug/kg (0.06mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BRAIN AND COVERINGS: RECORDINGS FROM SPECIFIC AREAS OF CNS

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Journal of Pharmacology and Experimental Therapeutics. Vol. 87, Pg. 90, 1946.
dog LD50 oral 100ug/kg (0.1mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

CARDIAC: ARRHYTHMIAS (INCLUDING CHANGES IN CONDUCTION)
National Technical Information Service. Vol. PB158-508,
dog LD50 subcutaneous 100ug/kg (0.1mg/kg) CARDIAC: ARRHYTHMIAS (INCLUDING CHANGES IN CONDUCTION)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
National Technical Information Service. Vol. PB158-508,
domestic animals - goat/sheep LC50 inhalation 200mg/m3/10M (200mg/m3) GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION

BEHAVIORAL: COMA
National Technical Information Service. Vol. PB158-508,
domestic animals - goat/sheep LD50 intramuscular 600ug/kg (0.6mg/kg) CARDIAC: ARRHYTHMIAS (INCLUDING CHANGES IN CONDUCTION) Journal of Pharmacology and Experimental Therapeutics. Vol. 87, Pg. 90, 1946.
domestic animals - goat/sheep LD50 intravenous 600ug/kg (0.6mg/kg) CARDIAC: ARRHYTHMIAS (INCLUDING CHANGES IN CONDUCTION) Journal of Pharmacology and Experimental Therapeutics. Vol. 87, Pg. 90, 1946.
domestic animals - goat/sheep LD50 oral 1mg/kg (1mg/kg) GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS

BEHAVIORAL: COMA

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION
National Technical Information Service. Vol. PB158-508,
domestic animals - goat/sheep LD50 subcutaneous 1mg/kg (1mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION

GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS

BEHAVIORAL: COMA
National Technical Information Service. Vol. PB158-508,
frog LD50 subcutaneous 100ug/kg (0.1mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

CARDIAC: ARRHYTHMIAS (INCLUDING CHANGES IN CONDUCTION)

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
National Technical Information Service. Vol. PB158-508,
frog LD50 unreported 300mg/kg (300mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE)
Journal of Pharmacology and Experimental Therapeutics. Vol. 87, Pg. 90, 1946.
guinea pig LC50 inhalation 100mg/m3/10M (100mg/m3) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Journal of the Chemical Society. Vol. -, Pg. 1773, 1948.
guinea pig LD50 intraperitoneal 350ug/kg (0.35mg/kg) BEHAVIORAL: TREMOR

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Journal of Pharmacology and Experimental Therapeutics. Vol. 87, Pg. 90, 1946.
guinea pig LD50 oral 500ug/kg (0.5mg/kg) BEHAVIORAL: COMA

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION

GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS
National Technical Information Service. Vol. PB158-508,
guinea pig LD50 subcutaneous 200ug/kg (0.2mg/kg) BEHAVIORAL: COMA

GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION
National Technical Information Service. Vol. PB158-508,
hamster LD50 intraperitoneal 2500ug/kg (2.5mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: EXCITEMENT

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Journal of Pharmacology and Experimental Therapeutics. Vol. 87, Pg. 90, 1946.
horse/donkey LD50 intramuscular 500ug/kg (0.5mg/kg) BRAIN AND COVERINGS: RECORDINGS FROM SPECIFIC AREAS OF CNS

BEHAVIORAL: EXCITEMENT

CARDIAC: ARRHYTHMIAS (INCLUDING CHANGES IN CONDUCTION)
Journal of Pharmacology and Experimental Therapeutics. Vol. 87, Pg. 90, 1946.
man TDLo oral 650ug/kg (0.65mg/kg) GASTROINTESTINAL: NAUSEA OR VOMITING National Technical Information Service. Vol. PB158-508,
monkey LC50 inhalation 800mg/m3/10M (800mg/m3) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

CARDIAC: ARRHYTHMIAS (INCLUDING CHANGES IN CONDUCTION)
National Technical Information Service. Vol. PB158-508,
monkey LD50 intravenous 4mg/kg (4mg/kg) BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)

GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Journal of Pharmacology and Experimental Therapeutics. Vol. 87, Pg. 90, 1946.
monkey LD50 oral 10mg/kg (10mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

CARDIAC: ARRHYTHMIAS (INCLUDING CHANGES IN CONDUCTION)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
National Technical Information Service. Vol. PB158-508,
monkey LD50 subcutaneous 10mg/kg (10mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

CARDIAC: ARRHYTHMIAS (INCLUDING CHANGES IN CONDUCTION)
National Technical Information Service. Vol. PB158-508,
monkey LD50 unreported > 50mg/kg (50mg/kg)   Pharmacological Reviews. Vol. 1, Pg. 383, 1949.
mouse LC50 inhalation 3200mg/m3/10M (3200mg/m3)   Nature. Vol. 160, Pg. 179, 1947.
mouse LD50 intraperitoneal 7500ug/kg (7.5mg/kg)   Journal of Organic Chemistry. Vol. 21, Pg. 883, 1956.
mouse LD50 intravenous 17mg/kg (17mg/kg) GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION

BEHAVIORAL: COMA
National Technical Information Service. Vol. PB158-508,
mouse LD50 oral 5mg/kg (5mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

CARDIAC: ARRHYTHMIAS (INCLUDING CHANGES IN CONDUCTION)
National Technical Information Service. Vol. PB158-508,
mouse LD50 parenteral 6mg/kg (6mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Journal of the Chemical Society. Vol. -, Pg. 1279, 1949.
mouse LD50 subcutaneous 5mg/kg (5mg/kg) CARDIAC: ARRHYTHMIAS (INCLUDING CHANGES IN CONDUCTION)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
National Technical Information Service. Vol. PB158-508,
pig LD50 intraperitoneal 400ug/kg (0.4mg/kg) CARDIAC: ARRHYTHMIAS (INCLUDING CHANGES IN CONDUCTION)

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Journal of Pharmacology and Experimental Therapeutics. Vol. 87, Pg. 90, 1946.
rabbit LC50 inhalation 25mg/m3/10M (25mg/m3)   Nature. Vol. 160, Pg. 179, 1947.
rabbit LD50 intravenous 200ug/kg (0.2mg/kg) CARDIAC: ARRHYTHMIAS (INCLUDING CHANGES IN CONDUCTION)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Journal of Pharmacology and Experimental Therapeutics. Vol. 87, Pg. 90, 1946.
rabbit LD50 oral 500ug/kg (0.5mg/kg) GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS

BEHAVIORAL: COMA

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION
National Technical Information Service. Vol. PB158-508,
rabbit LD50 skin 20mg/kg (20mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Journal of the Chemical Society. Vol. -, Pg. 1773, 1948.
rabbit LD50 subcutaneous 300ug/kg (0.3mg/kg) CARDIAC: ARRHYTHMIAS (INCLUDING CHANGES IN CONDUCTION)

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
National Technical Information Service. Vol. PB158-508,
rat LC50 inhalation 300mg/m3/10M (300mg/m3)   Nature. Vol. 160, Pg. 179, 1947.
rat LD50 intramuscular 2500ug/kg (2.5mg/kg)   Nature. Vol. 160, Pg. 179, 1947.
rat LD50 oral 3500ug/kg (3.5mg/kg) CARDIAC: ARRHYTHMIAS (INCLUDING CHANGES IN CONDUCTION)

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
National Technical Information Service. Vol. PB158-508,
rat LD50 subcutaneous 5mg/kg (5mg/kg) BEHAVIORAL: TREMOR

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: EXCITEMENT
Journal of Pharmacology and Experimental Therapeutics. Vol. 87, Pg. 90, 1946.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point -3.50E+01 deg C   EXP
Boiling Point 104.5 deg C   EXP
log P (octanol-water) 0.310 (none)   EST
Atmospheric OH Rate Constant 1.63E-13 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.