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Substance Name: Histone-lysine N-methyltransferase EZH2
RN: 459578-94-0
UNII: J2234208AE


  • A histone-lysine N-methyltransferase and catalytic subunit of Polycomb Repressive Complex 2. It methylates LYSINE 9 (H3K9me) and LYSINE 27 (H3K27me) of HISTONE H3, leading to transcriptional repression of the affected target gene. EZH2 also methylates non-histone proteins such as GATA4 TRANSCRIPTION FACTOR and the nuclear receptor RORA. It regulates CIRCADIAN CLOCKS via histone methylation at the PROMOTER REGIONS of the circadian genes and its repressive activity is also important for the identity and differentiation of EMBRYONIC STEM CELLS.
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Names and Synonyms

Name of Substance

  • Histone-lysine N-methyltransferase EZH2

MeSH Heading

  • Enhancer of Zeste Homolog 2 Protein


  • Enhancer of zeste 2 (human cell line bja-b gene ezh2)
  • Enhancer of zeste homolog 2
  • ENX-1
  • Histone-lysine N-methyltransferase EZH2
  • KMT6
  • Lysine N-methyltransferase 6
  • UNII-J2234208AE

Registry Numbers

CAS Registry Number

  • 459578-94-0


  • J2234208AE

System Generated Number

  • 0459578940