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Substance Name: Chlorphentermine [INN:BAN]
RN: 461-78-9
UNII: NHW07912O7
InChIKey: ZCKAMNXUHHNZLN-UHFFFAOYSA-N

Note

  • A sympathomimetic agent that was formerly used as an anorectic. It has properties similar to those of DEXTROAMPHETAMINE. It has been implicated in lipid storage disorders and pulmonary hypertension. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1223)

Molecular Formula

  • C10-H14-Cl-N

Molecular Weight

  • 183.6806
 

Classification Codes

Classification Codes

  • Autonomic Agents
  • Drug / Therapeutic Agent
  • Human Data
  • Mutation Data
  • Peripheral Nervous System Agents
  • Reproductive Effect
  • Sympathomimetics

Superlist Classification Code

  • DEA Schedule III
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Names and Synonyms

Name of Substance

  • Chlorphentermine
  • Chlorphentermine [INN:BAN]

MeSH Heading

  • Chlorphentermine

Synonyms

  • 1-(p-Chlorophenyl)-2-methyl-2-aminopropane
  • 1-(p-Chlorophenyl)-2-methyl-2-propylamine
  • 4-12-00-02823 (Beilstein Handbook Reference)
  • 4-Chloro-alpha,alpha-dimethylbenzeneethanamine
  • 4-Chloro-alpha,alpha-dimethylphenethylamine
  • alpha,alpha-Dimethyl-p-chlorophenethylamine
  • Benzeneethanamine, 4-chloro-alpha,alpha-dimethyl-
  • beta-(p-Chlorophenyl)-alpha,alpha-dimethylethylamine
  • BRN 1099928
  • Chlorphentermine
  • Chlorphenterminum
  • Chlorphenterminum [INN-Latin]
  • Clorfentermina
  • Clorfentermina [INN-Spanish]
  • Desopimon
  • Effox
  • EINECS 207-314-9
  • HSDB 3303
  • Lucofen SA
  • p-Chloro-alpha,alpha-dimethylphenethylamine
  • Teramine
  • UNII-NHW07912O7

Systematic Names

  • Benzeneethanamine, 4-chloro-alpha,alpha-dimethyl-
  • Chlorphentermine
  • Phenethylamine, p-chloro-alpha,alpha-dimethyl-

Superlist Names

  • Chlorphentermine
  • DEA No. 1645

Registry Numbers

CAS Registry Number

  • 461-78-9

FDA UNII

  • NHW07912O7

Other Registry Number

  • 8057-30-5

System Generated Number

  • 0000461789

Structure Descriptors

InChI

1S/C10H14ClN/c1-10(2,12)7-8-3-5-9(11)6-4-8/h3-6H,7,12H2,1-2H3

InChIKey

ZCKAMNXUHHNZLN-UHFFFAOYSA-N

Smiles

c1c(ccc(c1)CC(C)(C)N)Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
man TDLo oral 5357ug/kg (5.357mg/kg) VASCULAR: BP ELEVATION NOT CHARACTERIZED IN AUTONOMIC SECTION

AUTONOMIC NERVOUS SYSTEM: SYMPATHOMIMETIC
Therapie. Vol. 34, Pg. 205, 1979.
mouse LD50 intraperitoneal 150mg/kg (150mg/kg)   Acta Pharmaceutica Suecica. Vol. 15, Pg. 87, 1978.
mouse LD50 intravenous 56mg/kg (56mg/kg)   U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. Vol. NX#00697,
mouse LD50 oral 270mg/kg (270mg/kg) BEHAVIORAL: EXCITEMENT

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION
Acta Poloniae Pharmaceutica Vol. 26, Pg. 598, 1969.
mouse LD50 subcutaneous 260mg/kg (260mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: EXCITEMENT

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION
Acta Poloniae Pharmaceutica Vol. 26, Pg. 598, 1969.
rat LD50 oral 250mg/kg (250mg/kg)   Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 65(6), Pg. 218S, 1969.

Physical Properties

Physical Property Value Units Temp (deg C) Source
log P (octanol-water) 2.6 (none)   EXP
Water Solubility 3240 mg/L 25 EST
Vapor Pressure 0.014 mm Hg 25 EST
Henry's Law Constant 1.06E-06 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 2.42E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.