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Substance Name: Prifinium bromide [INN:JAN]
RN: 4630-95-9
UNII: 3B7O9ZC520
InChIKey: UCGJZJXOPSNTGZ-UHFFFAOYSA-M

Note

  • Quaternary ammonium anticholinergic agent more specific for the gastrointestinal tract than atropine.

Molecular Formula

  • C22-H28-N.Br

Molecular Weight

  • 386.374
 

Classification Codes

  • Drug / Therapeutic Agent
  • Reproductive Effect
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Names and Synonyms

Name of Substance

  • Prifinium bromide
  • Prifinium bromide [INN:JAN]
  • Pyrodifenium bromide

Synonyms

  • 1,1-Diethyl-2-methyl-3-diphenylmethylenepyrrolidinium bromide
  • 3-(Diphenylmethylene)-1,1-diethyl-2-methylpyrrolidinium bromide
  • 3-(Diphenylmethylene)-1-ethyl-2-methylpyrrolidine ethyl bromide
  • Bromure de prifinium
  • Bromure de prifinium [INN-French]
  • Bromuro de prifinio
  • Bromuro de prifinio [INN-Spanish]
  • EINECS 225-051-8
  • Padrin
  • PDB
  • Prifinii bromidum
  • Prifinii bromidum [INN-Latin]
  • Prifinio bromuro
  • Prifinio bromuro [DCIT]
  • Prifinium bromide
  • Pyrodifenium bromide
  • Riabal
  • UNII-3B7O9ZC520

Systematic Names

  • 3-(Diphenylmethylene)-1,1-diethyl-2-methylpyrrolidinium bromide
  • Prifinium bromide
  • Pyrrolidinium, 1,1-diethyl-3-diphenylmethylene-2-methyl-, bromide
  • Pyrrolidinium, 3-(diphenylmethylene)-1,1-diethyl-2-methyl-, bromide

Registry Numbers

CAS Registry Number

  • 4630-95-9

FDA UNII

  • 3B7O9ZC520

System Generated Number

  • 0004630959

Molecular Formulas

Molecular Formula

  • C22-H28-N.Br

Molecular Formula Fragments

  • Br
  • C22-H28-N
  • COMPONENT

Structure Descriptors

InChI

1S/C22H28N.BrH/c1-4-23(5-2)17-16-21(18(23)3)22(19-12-8-6-9-13-19)20-14-10-7-11-15-20;/h6-15,18H,4-5,16-17H2,1-3H3;1H/q+1;/p-1

InChIKey

UCGJZJXOPSNTGZ-UHFFFAOYSA-M

Smiles

C(=C1\[C@@H]([N+](CC)(CC)CC1)C)(\c1ccccc1)c1ccccc1.[BrH-]

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 intravenous 18mg/kg (18mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Arzneimittel-Forschung. Drug Research. Vol. 22, Pg. 706, 1972.
dog LD50 oral 327mg/kg (327mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Arzneimittel-Forschung. Drug Research. Vol. 22, Pg. 706, 1972.
dog LD50 subcutaneous 88mg/kg (88mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Arzneimittel-Forschung. Drug Research. Vol. 22, Pg. 706, 1972.
mouse LD50 intraperitoneal 40mg/kg (40mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Arzneimittel-Forschung. Drug Research. Vol. 22, Pg. 706, 1972.
mouse LD50 intravenous 11mg/kg (11mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Arzneimittel-Forschung. Drug Research. Vol. 22, Pg. 706, 1972.
mouse LD50 oral 310mg/kg (310mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Arzneimittel-Forschung. Drug Research. Vol. 22, Pg. 706, 1972.
mouse LD50 subcutaneous 30mg/kg (30mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Arzneimittel-Forschung. Drug Research. Vol. 22, Pg. 706, 1972.
rat LD50 intraperitoneal 46mg/kg (46mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Arzneimittel-Forschung. Drug Research. Vol. 22, Pg. 706, 1972.
rat LD50 intravenous 5500ug/kg (5.5mg/kg) SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE

AUTONOMIC NERVOUS SYSTEM: "SMOOTH MUSCLE RELAXANT (MECHANISM UNDEFINED, SPASMOLYTIC)"
Oyo Yakuri. Pharmacometrics. Vol. 23, Pg. 461, 1982.
rat LD50 oral 1090mg/kg (1090mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Arzneimittel-Forschung. Drug Research. Vol. 22, Pg. 706, 1972.
rat LD50 subcutaneous 170mg/kg (170mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Arzneimittel-Forschung. Drug Research. Vol. 22, Pg. 706, 1972.