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Substance Name: Prifinium bromide [INN:JAN]
RN: 4630-95-9
UNII: 3B7O9ZC520
InChIKey: UCGJZJXOPSNTGZ-UHFFFAOYSA-M
Note
- Quaternary ammonium anticholinergic agent more specific for the gastrointestinal tract than atropine.
Molecular Formula
- C22-H28-N.Br
Molecular Weight
- 386.374
- All
- Classifications
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- Names & Synonyms
- Registry Numbers
- Formulas
- Structure Descriptors
- Toxicity
Classification Codes
- Drug / Therapeutic Agent
- Reproductive Effect
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Names and Synonyms
Name of Substance
- Prifinium bromide
- Prifinium bromide [INN:JAN]
- Pyrodifenium bromide
Synonyms
- 1,1-Diethyl-2-methyl-3-diphenylmethylenepyrrolidinium bromide
- 3-(Diphenylmethylene)-1,1-diethyl-2-methylpyrrolidinium bromide
- 3-(Diphenylmethylene)-1-ethyl-2-methylpyrrolidine ethyl bromide
- Bromure de prifinium
- Bromure de prifinium [INN-French]
- Bromuro de prifinio
- Bromuro de prifinio [INN-Spanish]
- EINECS 225-051-8
- Padrin
- PDB
- Prifinii bromidum
- Prifinii bromidum [INN-Latin]
- Prifinio bromuro
- Prifinio bromuro [DCIT]
- Prifinium bromide
- Pyrodifenium bromide
- Riabal
- UNII-3B7O9ZC520
Systematic Names
- 3-(Diphenylmethylene)-1,1-diethyl-2-methylpyrrolidinium bromide
- Prifinium bromide
- Pyrrolidinium, 1,1-diethyl-3-diphenylmethylene-2-methyl-, bromide
- Pyrrolidinium, 3-(diphenylmethylene)-1,1-diethyl-2-methyl-, bromide
Registry Numbers
CAS Registry Number
- 4630-95-9
FDA UNII
- 3B7O9ZC520
System Generated Number
- 0004630959
Molecular Formulas
Molecular Formula
- C22-H28-N.Br
Molecular Formula Fragments
- Br
- C22-H28-N
- COMPONENT
Structure Descriptors
InChI
InChI=1S/C22H28N.BrH/c1-4-23(5-2)17-16-21(18(23)3)22(19-12-8-6-9-13-19)20-14-10-7-11-15-20;/h6-15,18H,4-5,16-17H2,1-3H3;1H/q+1;/p-1InChIKey
UCGJZJXOPSNTGZ-UHFFFAOYSA-MSmiles
[Br-].CC[N+]1(CC)Toxicity
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
dog | LD50 | intravenous | 18mg/kg (18mg/kg) | LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) | Arzneimittel-Forschung. Drug Research. Vol. 22, Pg. 706, 1972. |
dog | LD50 | oral | 327mg/kg (327mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) | Arzneimittel-Forschung. Drug Research. Vol. 22, Pg. 706, 1972. |
dog | LD50 | subcutaneous | 88mg/kg (88mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: DYSPNEA | Arzneimittel-Forschung. Drug Research. Vol. 22, Pg. 706, 1972. |
mouse | LD50 | intraperitoneal | 40mg/kg (40mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) | Arzneimittel-Forschung. Drug Research. Vol. 22, Pg. 706, 1972. |
mouse | LD50 | intravenous | 11mg/kg (11mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Arzneimittel-Forschung. Drug Research. Vol. 22, Pg. 706, 1972. |
mouse | LD50 | oral | 310mg/kg (310mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) | Arzneimittel-Forschung. Drug Research. Vol. 22, Pg. 706, 1972. |
mouse | LD50 | subcutaneous | 30mg/kg (30mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Arzneimittel-Forschung. Drug Research. Vol. 22, Pg. 706, 1972. |
rat | LD50 | intraperitoneal | 46mg/kg (46mg/kg) | LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) | Arzneimittel-Forschung. Drug Research. Vol. 22, Pg. 706, 1972. |
rat | LD50 | intravenous | 5500ug/kg (5.5mg/kg) | SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE AUTONOMIC NERVOUS SYSTEM: "SMOOTH MUSCLE RELAXANT (MECHANISM UNDEFINED, SPASMOLYTIC)" | Oyo Yakuri. Pharmacometrics. Vol. 23, Pg. 461, 1982. |
rat | LD50 | oral | 1090mg/kg (1090mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) | Arzneimittel-Forschung. Drug Research. Vol. 22, Pg. 706, 1972. |
rat | LD50 | subcutaneous | 170mg/kg (170mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) | Arzneimittel-Forschung. Drug Research. Vol. 22, Pg. 706, 1972. |