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Substance Name: Naloxone [INN:BAN]
RN: 465-65-6
UNII: 36B82AMQ7N
InChIKey: UZHSEJADLWPNLE-GRGSLBFTSA-N
Note
- A specific opiate antagonist that has no agonist activity. It is a competitive antagonist at mu, delta, and kappa opioid receptors.
Molecular Formula
- C19-H21-N-O4
Molecular Weight
- 327.3779
- All
- Classifications
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- Names & Synonyms
- Registry Numbers
- Structure Descriptors
- Toxicity
- Physical Properties
Classification Codes
- Central Nervous System Agents
- Drug / Therapeutic Agent
- Mutation Data
- Narcotic Antagonists
- Peripheral Nervous System Agents
- Reproductive Effect
- Sensory System Agents
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Names and Synonyms
Name of Substance
- Naloxone
- Naloxone [INN:BAN]
MeSH Heading
- Naloxone
Synonyms
- 1-N-Allyl-14-hydroxynordihydromorphinone
- 1-N-Allyl-7,8-dihydro-14-hydroxynormorphinone
- 12-Allyl-7,7a,8,9-tetrahydro-3,7a-dihydroxy-4aH-8,9c-iminoethanophenanthro(4,5-bcd)furanone
- 17-Allyl-4,5-alpha-epoxy-3,14-dihydroxymorphinan-6-one
- 17-Allyl-4,5alpha-epoxy-3,14-dihydroxymorphinan-6-one
- BRN 1089071
- EINECS 207-365-7
- EN 1530 base
- HSDB 3279
- l-N-Allyl-14-hydroxynordihydromorphinone
- l-N-Allyl-7,8-dihydro-14-hydroxynormorphinone
- l-Naloxone
- Morphinan-6-one, 17-allyl-4,5alpha-epoxy-3,14-dihydroxy-
- Morphinan-6-one, 4,5-epoxy-3,14-dihydroxy-17-(2-propenyl)-, (5alpha)-
- Morphinan-6-one, 4,5alpha-epoxy-3,14-dihydroxy-17-(2-propenyl)-
- N-Allyl-4,5alpha-epoxy-3,14-dihydroxy-6-morphinanon
- N-Allyl-noroxymorphone
- n-Allylnoroxymorphone
- Nalossone
- Nalossone [DCIT]
- Naloxona
- Naloxona [INN-Spanish]
- Naloxone
- Naloxone Nasal Spray
- Naloxonum
- Naloxonum [INN-Latin]
- Normorphinone, N-allyl-7,8-dihydro-14-hydroxy-, (-)-
- NSC 70413
- UNII-36B82AMQ7N
Systematic Names
- Morphinan-6-one, 17-allyl-4,5alpha-epoxy-3,14-dihydroxy- (8CI)
- Morphinan-6-one, 4,5-alpha-epoxy-3,14-dihydroxy-17-(2-propenyl)-
- Morphinan-6-one, 4,5-epoxy-3,14-dihydroxy-17-(2-propenyl)-, (5alpha)-
- Naloxone
Registry Numbers
CAS Registry Number
- 465-65-6
FDA UNII
- 36B82AMQ7N
Related Registry Number
- 357-08-4 (hydrochloride)
System Generated Number
- 0000465656
Structure Descriptors
InChI
InChI=1S/C19H21NO4/c1-2-8-20-9-7-18-15-11-3-4-12(21)16(15)24-17(18)13(22)5-6-19(18,23)14(20)10-11/h2-4,14,17,21,23H,1,5-10H2/t14-,17+,18+,19-/m1/s1InChIKey
UZHSEJADLWPNLE-GRGSLBFTSA-NSmiles
Oc1ccc2C[C@H]3N(CC=C)Toxicity
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| mouse | LD50 | subcutaneous | 260mg/kg (260mg/kg) | Annals of the New York Academy of Sciences. Vol. 281, Pg. 321, 1976. |
Physical Properties
| Physical Property | Value | Units | Temp (deg C) | Source |
|---|---|---|---|---|
| log P (octanol-water) | 2.09 | (none) | EXP | |
| Water Solubility | 1420 | mg/L | 25 | EST |
| Vapor Pressure | 4.25E-11 | mm Hg | 25 | EST |
| Henry's Law Constant | 5.38E-19 | atm-m3/mole | 25 | EST |
| Atmospheric OH Rate Constant | 2.38E-10 | cm3/molecule-sec | 25 | EST |
Physical property data is provided to ChemIDplus by SRC, Inc.