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Substance Name: Naloxone [INN:BAN]
RN: 465-65-6
UNII: 36B82AMQ7N
InChIKey: UZHSEJADLWPNLE-GRGSLBFTSA-N

Note

  • A specific opiate antagonist that has no agonist activity. It is a competitive antagonist at mu, delta, and kappa opioid receptors.

Molecular Formula

  • C19-H21-N-O4

Molecular Weight

  • 327.3779
 

Classification Codes

  • Central Nervous System Agents
  • Drug / Therapeutic Agent
  • Mutation Data
  • Narcotic Antagonists
  • Peripheral Nervous System Agents
  • Reproductive Effect
  • Sensory System Agents

Names and Synonyms

Name of Substance

  • Naloxone
  • Naloxone [INN:BAN]

MeSH Heading

  • Naloxone

Synonyms

  • 1-N-Allyl-14-hydroxynordihydromorphinone
  • 1-N-Allyl-7,8-dihydro-14-hydroxynormorphinone
  • 12-Allyl-7,7a,8,9-tetrahydro-3,7a-dihydroxy-4aH-8,9c-iminoethanophenanthro(4,5-bcd)furanone
  • 17-Allyl-4,5-alpha-epoxy-3,14-dihydroxymorphinan-6-one
  • 17-Allyl-4,5alpha-epoxy-3,14-dihydroxymorphinan-6-one
  • BRN 1089071
  • EINECS 207-365-7
  • EN 1530 base
  • HSDB 3279
  • l-N-Allyl-14-hydroxynordihydromorphinone
  • l-N-Allyl-7,8-dihydro-14-hydroxynormorphinone
  • l-Naloxone
  • Morphinan-6-one, 17-allyl-4,5alpha-epoxy-3,14-dihydroxy-
  • Morphinan-6-one, 4,5-epoxy-3,14-dihydroxy-17-(2-propenyl)-, (5alpha)-
  • Morphinan-6-one, 4,5alpha-epoxy-3,14-dihydroxy-17-(2-propenyl)-
  • N-Allyl-4,5alpha-epoxy-3,14-dihydroxy-6-morphinanon
  • N-Allyl-noroxymorphone
  • n-Allylnoroxymorphone
  • Nalossone
  • Nalossone [DCIT]
  • Naloxona
  • Naloxona [INN-Spanish]
  • Naloxone
  • Naloxone Nasal Spray
  • Naloxonum
  • Naloxonum [INN-Latin]
  • Normorphinone, N-allyl-7,8-dihydro-14-hydroxy-, (-)-
  • NSC 70413
  • UNII-36B82AMQ7N

Systematic Names

  • Morphinan-6-one, 17-allyl-4,5alpha-epoxy-3,14-dihydroxy- (8CI)
  • Morphinan-6-one, 4,5-alpha-epoxy-3,14-dihydroxy-17-(2-propenyl)-
  • Morphinan-6-one, 4,5-epoxy-3,14-dihydroxy-17-(2-propenyl)-, (5alpha)-
  • Naloxone

Registry Numbers

CAS Registry Number

  • 465-65-6

FDA UNII

  • 36B82AMQ7N

Related Registry Number

  • 357-08-4 (hydrochloride)

System Generated Number

  • 0000465656

Structure Descriptors

InChI

1S/C19H21NO4/c1-2-8-20-9-7-18-15-11-3-4-12(21)16(15)24-17(18)13(22)5-6-19(18,23)14(20)10-11/h2-4,14,17,21,23H,1,5-10H2/t14-,17+,18+,19-/m1/s1

InChIKey

UZHSEJADLWPNLE-GRGSLBFTSA-N

Smiles

Oc1ccc2C[C@H]3N(CC=C)CC[C@@]45[C@@H](Oc1c24)C(=O)CC[C@@]35O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 subcutaneous 260mg/kg (260mg/kg)   Annals of the New York Academy of Sciences. Vol. 281, Pg. 321, 1976.

Physical Properties

Physical Property Value Units Temp (deg C) Source
log P (octanol-water) 2.09 (none)   EXP
Water Solubility 1420 mg/L 25 EST
Vapor Pressure 4.25E-11 mm Hg 25 EST
Henry's Law Constant 5.38E-19 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 2.38E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.