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Substance Name: Hydromorphone [INN:BAN]
RN: 466-99-9
UNII: Q812464R06
InChIKey: WVLOADHCBXTIJK-YNHQPCIGSA-N
Note
- An opioid analgesic made from MORPHINE and used mainly as an analgesic. It has a shorter duration of action than morphine.
Molecular Formula
- C17-H19-N-O3
Molecular Weight
- 285.3411
- All
- Classifications
- Links to Resources
- Names & Synonyms
- Registry Numbers
- Structure Descriptors
- Toxicity
- Physical Properties
Classification Codes
Classification Codes
- Analgesics
- Analgesics, Opioid
- Central Nervous System Agents
- Central Nervous System Depressants
- Drug / Therapeutic Agent
- Human Data
- Narcotics
- Peripheral Nervous System Agents
- Sensory System Agents
Superlist Classification Code
- DEA Schedule II
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Regulatory Agencies (Superlist Locators)
Other Resources (Internet Locators)
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Names and Synonyms
Name of Substance
- Hydromorphone
- Hydromorphone [INN:BAN]
MeSH Heading
- Hydromorphone
Synonyms
- (-)-(5R)-4,5-Epoxy-3-hydroxy-9alpha-methylmorphinan-6-one
- 4,5-Epoxy-3-hydroxy-17-methylmorphinan-6-one
- 4,5alpha-Epoxy-3-hydroxy-17-methyl-6-morphinanone
- 6-Deoxy-7,8-dihydro-6-oxomorphine
- 7,8-Dihydromorphinone
- Dihydromorfinon
- Dihydromorfinon [Czech]
- Dihydromorphinone
- Dilaudid Oros
- DiMo
- Dimorphone
- EINECS 207-383-5
- Hidromorfona
- Hidromorfona [INN-Spanish]
- HSDB 3341
- Hydromorfona
- Hydromorfona [Spanish]
- Hydromorphone
- Hydromorphonum
- Hydromorphonum [INN-Latin]
- Idromorfone
- Idromorfone [DCIT]
- Laudacon
- Morphinan-6-one, 4,5-alpha-epoxy-3-hydroxy-17-methyl-
- Morphinan-6-one, 4,5-epoxy-3-hydroxy-17-methyl-, (5alpha)-
- Morphinone, dihydro-
- Novolaudon
- NSC 19046
- UNII-Q812464R06
Systematic Names
- Hydromorphone
- Morphinan-6-one, 4,5-alpha-epoxy-3-hydroxy-17-methyl-
- Morphinan-6-one, 4,5-epoxy-3-hydroxy-17-methyl-, (5alpha)-
- Morphinan-6-one, 4,5alpha-epoxy-3-hydroxy-17-methyl- (8CI)
Superlist Names
- DEA No. 9150
- Hydromorphone
Registry Numbers
CAS Registry Number
- 466-99-9
FDA UNII
- Q812464R06
Other Registry Numbers
- 18145-12-5
- 41376-02-7
System Generated Number
- 0000466999
Structure Descriptors
InChI
InChI=1S/C17H19NO3/c1-18-7-6-17-10-3-5-13(20)16(17)21-15-12(19)4-2-9(14(15)17)8-11(10)18/h2,4,10-11,16,19H,3,5-8H2,1H3/t10-,11+,16-,17-/m0/s1InChIKey
WVLOADHCBXTIJK-YNHQPCIGSA-NSmiles
CN1CC[C@@]23[C@H]4CCC(=O)Toxicity
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
human | LDLo | oral | 1428ug/kg (1.428mg/kg) | "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969Vol. -, Pg. 223, 1969. | |
mouse | LD50 | intravenous | 104mg/kg (104mg/kg) | BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) PERIPHERAL NERVE AND SENSATION: LOCAL ANESTHETIC LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION | Yakugaku Zasshi. Journal of Pharmacy. Vol. 84, Pg. 268, 1964. |
mouse | LD50 | subcutaneous | 84mg/kg (84mg/kg) | BEHAVIORAL: STIFFNESS BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) | Journal of Pharmacology and Experimental Therapeutics. Vol. 52, Pg. 468, 1934. |
Physical Properties
Physical Property | Value | Units | Temp (deg C) | Source |
---|---|---|---|---|
Melting Point | 266.5 | deg C | EXP | |
log P (octanol-water) | 1.600 | (none) | EST | |
Atmospheric OH Rate Constant | 2.01E-10 | cm3/molecule-sec | 25 | EST |
Physical property data is provided to ChemIDplus by SRC, Inc.