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Substance Name: Hydromorphone [INN:BAN]
RN: 466-99-9
UNII: Q812464R06
InChIKey: WVLOADHCBXTIJK-YNHQPCIGSA-N

Note

  • An opioid analgesic made from MORPHINE and used mainly as an analgesic. It has a shorter duration of action than morphine.

Molecular Formula

  • C17-H19-N-O3

Molecular Weight

  • 285.3411
 

Classification Codes

Classification Codes

  • Analgesics
  • Analgesics, Opioid
  • Central Nervous System Agents
  • Central Nervous System Depressants
  • Drug / Therapeutic Agent
  • Human Data
  • Narcotics
  • Peripheral Nervous System Agents
  • Sensory System Agents

Superlist Classification Code

  • DEA Schedule II

Names and Synonyms

Name of Substance

  • Hydromorphone
  • Hydromorphone [INN:BAN]

MeSH Heading

  • Hydromorphone

Synonyms

  • (-)-(5R)-4,5-Epoxy-3-hydroxy-9alpha-methylmorphinan-6-one
  • 4,5-Epoxy-3-hydroxy-17-methylmorphinan-6-one
  • 4,5alpha-Epoxy-3-hydroxy-17-methyl-6-morphinanone
  • 6-Deoxy-7,8-dihydro-6-oxomorphine
  • 7,8-Dihydromorphinone
  • Dihydromorfinon
  • Dihydromorfinon [Czech]
  • Dihydromorphinone
  • Dilaudid Oros
  • DiMo
  • Dimorphone
  • EINECS 207-383-5
  • Hidromorfona
  • Hidromorfona [INN-Spanish]
  • HSDB 3341
  • Hydromorfona
  • Hydromorfona [Spanish]
  • Hydromorphone
  • Hydromorphonum
  • Hydromorphonum [INN-Latin]
  • Idromorfone
  • Idromorfone [DCIT]
  • Laudacon
  • Morphinan-6-one, 4,5-alpha-epoxy-3-hydroxy-17-methyl-
  • Morphinan-6-one, 4,5-epoxy-3-hydroxy-17-methyl-, (5alpha)-
  • Morphinone, dihydro-
  • Novolaudon
  • NSC 19046
  • UNII-Q812464R06

Systematic Names

  • Hydromorphone
  • Morphinan-6-one, 4,5-alpha-epoxy-3-hydroxy-17-methyl-
  • Morphinan-6-one, 4,5-epoxy-3-hydroxy-17-methyl-, (5alpha)-
  • Morphinan-6-one, 4,5alpha-epoxy-3-hydroxy-17-methyl- (8CI)

Superlist Names

  • DEA No. 9150
  • Hydromorphone

Registry Numbers

CAS Registry Number

  • 466-99-9

FDA UNII

  • Q812464R06

Other Registry Numbers

  • 18145-12-5
  • 41376-02-7

System Generated Number

  • 0000466999

Structure Descriptors

InChI

InChI=1S/C17H19NO3/c1-18-7-6-17-10-3-5-13(20)16(17)21-15-12(19)4-2-9(14(15)17)8-11(10)18/h2,4,10-11,16,19H,3,5-8H2,1H3/t10-,11+,16-,17-/m0/s1

InChIKey

WVLOADHCBXTIJK-YNHQPCIGSA-N

Smiles

CN1CC[C@@]23[C@H]4CCC(=O)[C@@H]2Oc5c(O)ccc(C[C@@H]14)c35

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
human LDLo oral 1428ug/kg (1.428mg/kg)   "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969Vol. -, Pg. 223, 1969.
mouse LD50 intravenous 104mg/kg (104mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

PERIPHERAL NERVE AND SENSATION: LOCAL ANESTHETIC

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION		 Yakugaku Zasshi. Journal of Pharmacy. Vol. 84, Pg. 268, 1964.
mouse LD50 subcutaneous 84mg/kg (84mg/kg) BEHAVIORAL: STIFFNESS

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)		 Journal of Pharmacology and Experimental Therapeutics. Vol. 52, Pg. 468, 1934.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 266.5 deg C   EXP
log P (octanol-water) 1.600 (none)   EST
Atmospheric OH Rate Constant 2.01E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.