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Substance Name: Oripavine
RN: 467-04-9
UNII: 575AOU51CR
InChIKey: ZKLXUUYLEHCAMF-UUWFMWQGSA-N

Note

  • From, Papaver orientale L. & P. bacterium Lindl.

Classification Code

  • Drug / Therapeutic Agent

Molecular Formula

  • C18-H19-N-O3

Molecular Weight

  • 297.3521
 
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Names and Synonyms

Name of Substance

  • Oripavine

Synonyms

  • 4-27-00-02270 (Beilstein Handbook Reference)
  • 6,7,8,14-Tetradehydro-4,5-alpha-epoxy-6-methoxy-17-methyl-morphinan-3-ol
  • BRN 0046094
  • EINECS 207-385-6
  • Oripavine
  • UNII-575AOU51CR

Systematic Names

  • (5alpha)-6,7,8,14-Tetradehydro-4,5-epoxy-6-methoxy-17-methylmorphinan-3-ol
  • Morphinan-3-ol, 6,7,8,14-tetradehydro-4,5-alpha-epoxy-6-methoxy-17-methyl-

Superlist Names

  • DEA No. 9330
  • Oripavine

Registry Numbers

CAS Registry Number

  • 467-04-9

FDA UNII

  • 575AOU51CR

System Generated Number

  • 0000467049

Structure Descriptors

InChI

1S/C18H19NO3/c1-19-8-7-18-11-4-6-14(21-2)17(18)22-16-13(20)5-3-10(15(16)18)9-12(11)19/h3-6,12,17,20H,7-9H2,1-2H3/t12-,17+,18+/m1/s1

InChIKey

ZKLXUUYLEHCAMF-UUWFMWQGSA-N

Smiles

COC1=CC=C2[C@H]3Cc4ccc(O)c5O[C@@H]1[C@]2(CCN3C)c45

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 26100ug/kg (26.1mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Phytotherapy Research. Vol. 12, Pg. 346, 1998.
mouse LD50 subcutaneous 11mg/kg (11mg/kg) BEHAVIORAL: ANALGESIA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: REGIDITY
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 254, Pg. 223, 1981.
rat LD50 subcutaneous 13mg/kg (13mg/kg) BEHAVIORAL: REGIDITY

BEHAVIORAL: ANALGESIA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 254, Pg. 223, 1981.