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Substance Name: Norcodeine [INN:BAN]
RN: 467-15-2
UNII: 32W9P3T4ML
InChIKey: HKOIXWVRNLGFOR-KOFBORESSA-N

Classification Code

  • Drug / Therapeutic Agent

Molecular Formula

  • C17-H19-N-O3

Molecular Weight

  • 285.3411
 
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Names and Synonyms

Name of Substance

  • Norcodeine
  • Norcodeine [INN:BAN]

Synonyms

  • (-)-N-Norcodeine
  • 7,8-Didehydro-4,5-alpha-epoxy-3-methoxymorphinan-6-alpha-ol
  • EINECS 207-388-2
  • N-Desmethylcodeine
  • N-Norcodeine
  • Norcodeina
  • Norcodeina [INN-Spanish]
  • Norcodeine
  • Norcodeinum
  • Norcodeinum [INN-Latin]
  • Normorphine 3-methyl ether
  • UNII-32W9P3T4ML

Systematic Names

  • Morphinan-6-alpha-ol, 7,8-didehydro-4,5-alpha-epoxy-3-methoxy-
  • Morphinan-6-ol, 7,8-didehydro-4,5-epoxy-3-methoxy-, (5-alpha,6-alpha)- (9CI)
  • N-Demethylcodeine
  • Norcodeine

Registry Numbers

CAS Registry Number

  • 467-15-2

FDA UNII

  • 32W9P3T4ML

Other Registry Number

  • 1410795-05-9

System Generated Number

  • 0000467152

Structure Descriptors

InChI

1S/C17H19NO3/c1-20-13-5-2-9-8-11-10-3-4-12(19)16-17(10,6-7-18-11)14(9)15(13)21-16/h2-5,10-12,16,18-19H,6-8H2,1H3/t10-,11+,12-,16-,17-/m0/s1

InChIKey

HKOIXWVRNLGFOR-KOFBORESSA-N

Smiles

COc1ccc2c3c1O[C@@H]4[C@]35CCN[C@H](C2)[C@@H]5C=C[C@@H]4O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 365mg/kg (365mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Journal of Pharmacology and Experimental Therapeutics. Vol. 112, Pg. 191, 1954.
mouse LD50 subcutaneous 600mg/kg (600mg/kg) BEHAVIORAL: ANALGESIA

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Chemical and Pharmaceutical Bulletin. Vol. 19, Pg. 1, 1971.

Physical Properties

Physical Property Value Units Temp (deg C) Source
pKa Dissociation Constant 9.23 (none) 25 EXP
log P (octanol-water) 0.69 (none)   EXP
Water Solubility 3.92E+04 mg/L 25 EST
Vapor Pressure 2.75E-09 mm Hg 25 EST
Henry's Law Constant 3.45E-14 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 2.39E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.