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Substance Name: Viloxazine [INN:BAN]
RN: 46817-91-8
UNII: 5I5Y2789ZF
InChIKey: YWPHCCPCQOJSGZ-UHFFFAOYSA-N

Note

  • A morpholine derivative used as an antidepressant. It is similar in action to IMIPRAMINE.

Molecular Formula

  • C13-H19-N-O3

Molecular Weight

  • 237.297
 

Classification Codes

  • Adrenergic Agents
  • Adrenergic Uptake Inhibitors
  • Antidepressive Agents
  • Antidepressive Agents, Second-Generation
  • Central Nervous System Agents
  • Membrane Transport Modulators
  • Neurotransmitter Agents
  • Neurotransmitter Uptake Inhibitors
  • Psychotropic Drugs
  • Reproductive Effect
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Names and Synonyms

Name of Substance

  • Viloxazine
  • Viloxazine [INN:BAN]

MeSH Heading

  • Viloxazine

Synonyms

  • 2-((2-Ethoxyphenoxy)methyl)morpholine
  • 2-(2-Ethoxyphenoxymethyl)tetrahydro-1,4-oxazine
  • CCRIS 9180
  • EINECS 256-281-7
  • Emovit
  • UNII-5I5Y2789ZF
  • Viloxazin
  • Viloxazina
  • Viloxazina [INN-Spanish]
  • Viloxazine
  • Viloxazinum
  • Viloxazinum [INN-Latin]

Systematic Names

  • Morpholine, 2-((2-ethoxyphenoxy)methyl)-
  • Viloxazine

Registry Numbers

CAS Registry Number

  • 46817-91-8

FDA UNII

  • 5I5Y2789ZF

Related Registry Number

  • 35604-67-2 (hydrochloride)

System Generated Number

  • 0046817918

Structure Descriptors

InChI

1S/C13H19NO3/c1-2-15-12-5-3-4-6-13(12)17-10-11-9-14-7-8-16-11/h3-6,11,14H,2,7-10H2,1H3

InChIKey

YWPHCCPCQOJSGZ-UHFFFAOYSA-N

Smiles

c1(c(cccc1)OCC)OC[C@@H]1CNCCO1

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intravenous 60mg/kg (60mg/kg) BEHAVIORAL: MUSCLE WEAKNESS

BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)

BEHAVIORAL: ATAXIA
Handbook of Experimental Pharmacology. Vol. 55, Pg. 527, 1980.
mouse LD50 oral 552mg/kg (552mg/kg)   European Journal of Medicinal Chemistry--Chimie Therapeutique. Vol. 27, Pg. 437, 1992.
rat LD50 intravenous 60mg/kg (60mg/kg) BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)

BEHAVIORAL: MUSCLE WEAKNESS

BEHAVIORAL: ATAXIA
Handbook of Experimental Pharmacology. Vol. 55, Pg. 527, 1980.
rat LD50 oral 2gm/kg (2000mg/kg) BEHAVIORAL: ATAXIA

BEHAVIORAL: MUSCLE WEAKNESS

BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)
Handbook of Experimental Pharmacology. Vol. 55, Pg. 527, 1980.

Physical Properties

Physical Property Value Units Temp (deg C) Source
log P (octanol-water) 1.750 (none)   EST
Atmospheric OH Rate Constant 1.77E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.