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Substance Name: Trichodermin
RN: 4682-50-2
UNII: WF22557W91
InChIKey: HNEGCRMUYSKRRR-IKIFYQGPSA-N

Note

  • Antifungal metabolite from several fungi, mainly Trichoderma viride; inhibits protein synthesis by binding to ribosomes; proposed as antifungal and antineoplastic; used as tool in cellular biochemistry.

Molecular Formula

  • C17-H24-O4

Molecular Weight

  • 292.373
 

Classification Code

  • Drug / Therapeutic Agent
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Names and Synonyms

Name of Substance

  • Trichodermin

MeSH Heading

  • Trichodermin

Synonyms

  • 12,13-Epoxytrichothec-9-en-4-ol acetate
  • ND 8
  • NSC 267033
  • NSC 73846
  • Trichodermin
  • Trichoderonin
  • Trichothec-9-en-4-ol, 12,13-epoxy-, acetate
  • UNII-WF22557W91
  • WG 696

Systematic Names

  • Trichothec-9-en-4-ol, 12,13-epoxy-, acetate
  • Trichothec-9-en-4-ol, 12,13-epoxy-, acetate, (4beta)-
  • Trichothec-9-en-4beta-ol, 12,13-epoxy-,, acetate (8CI)

Registry Numbers

CAS Registry Number

  • 4682-50-2

FDA UNII

  • WF22557W91

System Generated Number

  • 0004682502

Structure Descriptors

InChI

1S/C17H24O4/c1-10-5-6-15(3)12(7-10)21-14-8-13(20-11(2)18)16(15,4)17(14)9-19-17/h7,12-14H,5-6,8-9H2,1-4H3/t12-,13-,14-,15+,16-,17+/m1/s1

InChIKey

HNEGCRMUYSKRRR-IKIFYQGPSA-N

Smiles

C1[C@@]2([C@]3([C@@]4([C@@H](C=C(C)CC4)O[C@@H]2C[C@H]3OC(C)=O)C)C)O1

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 500mg/kg (500mg/kg)   Bulletin du Cancer. Vol. 73, Pg. 402, 1986.
mouse LD50 subcutaneous 500mg/kg (500mg/kg)   Netherlands Application Patent Document. Vol. #302527,