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Substance Name: Cinobufagin
RN: 470-37-1
UNII: T9PSN4R8IR
InChIKey: SCULJPGYOQQXTK-OLRINKBESA-N

Note

  • Isolated from Chinese medicinal preparation ch'an su; derived from toad venom.

Classification Code

  • Drug / Therapeutic Agent

Molecular Formula

  • C26-H34-O6

Molecular Weight

  • 442.5486
 
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Names and Synonyms

Name of Substance

  • Cinobufagin

Synonyms

  • Cino-bufagin
  • Cinobufagine
  • NSC 90325
  • UNII-T9PSN4R8IR

Systematic Names

  • 5beta-Bufa-20,22-dienolide, 14,15beta-epoxy-3beta,16beta-dihydroxy-, 16-acetate (8CI)
  • Bufa-20,22-dienolide, 16-(acetyloxy)-14,15-epoxy-3-hydroxy-, (3-beta,5-beta,15-beta,16-beta)-

Registry Numbers

CAS Registry Number

  • 470-37-1

FDA UNII

  • T9PSN4R8IR

System Generated Number

  • 0000470371

Structure Descriptors

InChI

1S/C26H34O6/c1-14(27)31-22-21(15-4-7-20(29)30-13-15)25(3)11-9-18-19(26(25)23(22)32-26)6-5-16-12-17(28)8-10-24(16,18)2/h4,7,13,16-19,21-23,28H,5-6,8-12H2,1-3H3/t16-,17+,18+,19-,21+,22-,23-,24+,25-,26-/m1/s1

InChIKey

SCULJPGYOQQXTK-OLRINKBESA-N

Smiles

O1[C@]23[C@H]1[C@H](OC(C)=O)[C@@H]([C@@]2(CC[C@@H]1[C@@H]3CC[C@H]2[C@@]1(CC[C@@H](C2)O)C)C)c1cc(occ1)=O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
cat LDLo intravenous 230ug/kg (0.23mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 49, Pg. 561, 1933.
cat LDLo unreported 209ug/kg (0.209mg/kg)   Pharmaceutica Acta Helvetiae. Vol. 24, Pg. 222, 1949.
mouse LD50 intravenous 1210ug/kg (1.21mg/kg) BEHAVIORAL: TREMOR

BEHAVIORAL: ANTIPSYCHOTIC

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Chemical and Pharmaceutical Bulletin. Vol. 24, Pg. 1714, 1976.
mouse LD50 oral 144mg/kg (144mg/kg) SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: ATAXIA
Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 86, Pg. 269, 1985.