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Substance Name: Enoxolone [INN:BAN:DCF]
RN: 471-53-4
UNII: P540XA09DR
InChIKey: MPDGHEJMBKOTSU-YKLVYJNSSA-N
Note
- An oleanolic acid from GLYCYRRHIZA that has some antiallergic, antibacterial, and antiviral properties. It is used topically for allergic or infectious skin inflammation and orally for its aldosterone effects in electrolyte regulation.
Molecular Formula
- C30-H46-O4
Molecular Weight
- 470.6894
- All
- Classifications
- Links to Resources
- Names & Synonyms
- Registry Numbers
- Structure Descriptors
- Toxicity
- Physical Properties
Classification Code
- Anti-Inflammatory Agents
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Names and Synonyms
Results Name
- Enoxolone [INN:BAN:DCF]
Name of Substance
- (3beta,20beta)-3-Hydroxy-11-oxo-olean-12-en-29-oic acid
- Enoxolone [INN:BAN:DCF]
- Glycyrrhetic acid
- Glycyrrhetinic acid [JAN]
- Olean-12-en-29-oic acid, 3-hydroxy-11-oxo-, (3beta,20beta)-
MeSH Heading
- Glycyrrhetinic acid
Synonyms
- 18-beta-Glycyrrhetic acid
- 18-beta-Glycyrrhetinic acid
- 18beta-Glycyrrhetinic acid
- 3-beta-Hydroxy-11-oxoolean-12-en-30-oic acid
- 3-Glycyrrhetinic acid
- 3beta-Hydroxy-11-oxoolean-12-en-30-oic acid
- 4-10-00-03775 (Beilstein Handbook Reference)
- alpha-Glycyrrhetinic acid
- Biosone
- BRN 2229654
- CCRIS 3962
- EINECS 207-444-6
- Enoxolona
- Enoxolona [INN-Spanish]
- Enoxolone
- Enoxolonum
- Enoxolonum [INN-Latin]
- Glycyrrhetic acid
- Glycyrrhetin
- Glycyrrhetinic acid
- NSC 35347
- UNII-P540XA09DR
- Uralenic acid
Systematic Names
- 18beta-Glycyrrhetinic acid
- 3beta-Hydroxy-11-oxoolean-12-en-30-oic acid
- Enoxolone
- Olean-12-en-29-oic acid, 3-hydroxy-11-oxo-, (3beta,20beta)-
- Olean-12-en-30-oic acid, 3-beta-hydroxy-11-oxo-
- Olean-12-en-30-oic acid, 3beta-hydroxy-11-oxo- (8CI)
Registry Numbers
CAS Registry Number
- 471-53-4
FDA UNII
- P540XA09DR
Other Registry Numbers
- 107420-91-7
- 15301-63-0
- 202522-39-2
- 2088830-40-2
- 299198-00-8
- 8055-71-8
System Generated Number
- 0000471534
Structure Descriptors
InChI
1S/C30H46O4/c1-25(2)21-8-11-30(7)23(28(21,5)10-9-22(25)32)20(31)16-18-19-17-27(4,24(33)34)13-12-26(19,3)14-15-29(18,30)6/h16,19,21-23,32H,8-15,17H2,1-7H3,(H,33,34)/t19-,21-,22-,23+,26+,27-,28-,29+,30+/m0/s1InChIKey
MPDGHEJMBKOTSU-YKLVYJNSSA-NSmiles
C[C@]12CC[C@](C[C@H]1C3=CC(=O)Toxicity
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
mouse | LD50 | intraperitoneal | 308mg/kg (308mg/kg) | Drugs in Japan Vol. -, Pg. 319, 1990. | |
mouse | LD50 | intravenous | 56mg/kg (56mg/kg) | U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. Vol. NX#02067, | |
mouse | LD50 | subcutaneous | 518mg/kg (518mg/kg) | Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 5, Pg. 98, 1963. |
Physical Properties
Physical Property | Value | Units | Temp (deg C) | Source |
---|---|---|---|---|
Melting Point | 296 | deg C | EXP | |
log P (octanol-water) | 6.900 | (none) | EST | |
Atmospheric OH Rate Constant | 1.12E-10 | cm3/molecule-sec | 25 | EST |
Physical property data is provided to ChemIDplus by SRC, Inc.