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Substance Name: Nuciferine
RN: 475-83-2
UNII: W26UEB90B7
InChIKey: ORJVQPIHKOARKV-OAHLLOKOSA-N

Note

  • CNS depressant; glutamic acid antagonist.

Classification Code

  • Drug / Therapeutic Agent

Molecular Formula

  • C19-H21-N-O2

Molecular Weight

  • 295.38
 
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Names and Synonyms

Name of Substance

  • Nuciferine

Synonyms

  • (-)-Nucipherine
  • (R)-1,2-Dimethoxyaporphine
  • 1,2-Dimethoxy-6abeta-aporphine
  • l-5,6-Dimethoxyaporphine
  • l-Nuciferine
  • Nuciferin
  • Nuciferine
  • Sanjoinine E
  • UNII-W26UEB90B7

Systematic Names

  • 4H-Dibenzo(de,g)quinoline, 5,6,6a,7-tetrahydro-1,2-dimethoxy-6-methyl-, (R)- (9CI)
  • 6a-beta-Aporphine, 1,2-dimethoxy-

Registry Numbers

CAS Registry Number

  • 475-83-2

FDA UNII

  • W26UEB90B7

System Generated Number

  • 0000475832

Structure Descriptors

InChI

1S/C19H21NO2/c1-20-9-8-13-11-16(21-2)19(22-3)18-14-7-5-4-6-12(14)10-15(20)17(13)18/h4-7,11,15H,8-10H2,1-3H3/t15-/m1/s1

InChIKey

ORJVQPIHKOARKV-OAHLLOKOSA-N

Smiles

c12c3[C@@H](Cc4c1cccc4)[N@@](CCc3cc(c2OC)OC)C

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 83mg/kg (83mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Journal of Pharmaceutical Sciences. Vol. 61, Pg. 813, 1972.
mouse LD50 oral 240mg/kg (240mg/kg) SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 197, Pg. 261, 1972.
rat LD50 oral 280mg/kg (280mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 197, Pg. 261, 1972.