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Substance Name: Tivozanib [USAN:INN]
RN: 475108-18-0
UNII: 172030934T
InChIKey: SPMVMDHWKHCIDT-UHFFFAOYSA-N

Note

  • NCI: An orally bioavailable inhibitor of vascular endothelial growth factor receptors (VEGFRs) 1, 2 and 3 with potential antiangiogenic and antineoplastic activities. Tivozanib binds to and inhibits VEGFRs 1, 2 and 3, which may result in the inhibition of endothelial cell migration and proliferation, inhibition of tumor angiogenesis and tumor cell death. VEGFR tyrosine kinases, frequently overexpressed by a variety of tumor cell types, play a key role in angiogenesis. (NCI Thesaurus)

Molecular Formula

  • C22-H19-Cl-N4-O5

Molecular Weight

  • 454.8681
 

Classification Code

  • Antineoplastic
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Names and Synonyms

Name of Substance

  • Tivozanib [USAN:INN]

Synonyms

  • AV 951
  • AV-951
  • AV951
  • KRN 951
  • KRN-951
  • N-(2-Chloro-4-((6,7-dimethoxy-4-quinolyl)oxy)phenyl)-N'-(5-methyl-3-isoxazolyl)urea
  • Tivozanib
  • UNII-172030934T

Systematic Name

  • Urea, N-(2-chloro-4-((6,7-dimethoxy-4-quinolinyl)oxy)phenyl)-N'-(5-methyl-3-isoxazolyl)-

Registry Numbers

CAS Registry Number

  • 475108-18-0

FDA UNII

  • 172030934T

System Generated Number

  • 0475108180

Structure Descriptors

InChI

1S/C22H19ClN4O5/c1-12-8-21(27-32-12)26-22(28)25-16-5-4-13(9-15(16)23)31-18-6-7-24-17-11-20(30-3)19(29-2)10-14(17)18/h4-11H,1-3H3,(H2,25,26,27,28)

InChIKey

SPMVMDHWKHCIDT-UHFFFAOYSA-N