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Substance Name: Sorafenib tosylate [USAN]
RN: 475207-59-1
UNII: 5T62Q3B36J
InChIKey: IVDHYUQIDRJSTI-UHFFFAOYSA-N

Note

  • Inhibits tumor cell proliferation and angiogenesis by targeting RAF KINASES and VEGF RECEPTORS; multikinase inhibitor that targets serine/threonine and receptor tyrosine kinases to decrease tumor growth and angiogenesis; FDA approved orphan drug indication for hepatocellular carcinoma in 2006.

Molecular Formula

  • C21-H16-Cl-F3-N4-O3.C7-H8-O3-S

Molecular Weight

  • 637.0326
 

Classification Code

  • Treatment of Cancer
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Names and Synonyms

Name of Substance

  • Sorafenib tosylate [USAN]

Synonyms

  • 1-(4-Chloro-3-(trifluoromethyl)phenyl)-3-(4-((2-(methylcarbamoyl)pyridin-4-yl)oxy)phenyl)urea mono(4-methylbenzenesulfonate)
  • 4-(4-(3-(4-Chloro-3-(trifluoromethyl)phenyl)ureido)phenoxy)-N2-methylpyridine-2-carboxamide mono (4-methylbenzenesulfonate)
  • BAY 43-9006 mono-p-tosylate
  • BAY 54-9085
  • BAY43-9006 mono-p-tosylate
  • Nexavar
  • Nexavar(R)
  • Sorafenib tosylate
  • UNII-5T62Q3B36J

Systematic Name

  • 2-Pyridinecarboxamide, 4-(4-((((4-chloro-3-(trifluoromethyl)phenyl)amino)carbonyl)amino)phenoxy)-N-methyl-, mono(4-methylbenzenesulfonate)

Registry Numbers

CAS Registry Number

  • 475207-59-1

FDA UNII

  • 5T62Q3B36J

System Generated Number

  • 0475207591

Molecular Formulas

Molecular Formula

  • C21-H16-Cl-F3-N4-O3.C7-H8-O3-S

Molecular Formula Fragments

  • C21-H16-Cl-F3-N4-O3
  • C7-H8-O3-S
  • COMPONENT

Structure Descriptors

InChI

InChI=1S/C21H16ClF3N4O3.C7H8O3S/c1-26-19(30)18-11-15(8-9-27-18)32-14-5-2-12(3-6-14)28-20(31)29-13-4-7-17(22)16(10-13)21(23,24)25;1-6-2-4-7(5-3-6)11(8,9)10/h2-11H,1H3,(H,26,30)(H2,28,29,31);2-5H,1H3,(H,8,9,10)

InChIKey

IVDHYUQIDRJSTI-UHFFFAOYSA-N

Smiles

CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)cc2)ccn1.Cc4ccc(cc4)S(=O)(=O)O