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Substance Name: Sorafenib tosylate [USAN]
RN: 475207-59-1
UNII: 5T62Q3B36J
InChIKey: IVDHYUQIDRJSTI-UHFFFAOYSA-N
Note
- Inhibits tumor cell proliferation and angiogenesis by targeting RAF KINASES and VEGF RECEPTORS; multikinase inhibitor that targets serine/threonine and receptor tyrosine kinases to decrease tumor growth and angiogenesis; FDA approved orphan drug indication for hepatocellular carcinoma in 2006.
Molecular Formula
- C21-H16-Cl-F3-N4-O3.C7-H8-O3-S
Molecular Weight
- 637.0326
Classification Code
- Treatment of Cancer
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Names and Synonyms
Name of Substance
- Sorafenib tosylate [USAN]
Synonyms
- 1-(4-Chloro-3-(trifluoromethyl)phenyl)-3-(4-((2-(methylcarbamoyl)pyridin-4-yl)oxy)phenyl)urea mono(4-methylbenzenesulfonate)
- 4-(4-(3-(4-Chloro-3-(trifluoromethyl)phenyl)ureido)phenoxy)-N2-methylpyridine-2-carboxamide mono (4-methylbenzenesulfonate)
- BAY 43-9006 mono-p-tosylate
- BAY 54-9085
- BAY43-9006 mono-p-tosylate
- Nexavar
- Nexavar(R)
- Sorafenib tosylate
- UNII-5T62Q3B36J
Systematic Name
- 2-Pyridinecarboxamide, 4-(4-((((4-chloro-3-(trifluoromethyl)phenyl)amino)carbonyl)amino)phenoxy)-N-methyl-, mono(4-methylbenzenesulfonate)
Registry Numbers
CAS Registry Number
- 475207-59-1
FDA UNII
- 5T62Q3B36J
System Generated Number
- 0475207591
Molecular Formulas
Molecular Formula
- C21-H16-Cl-F3-N4-O3.C7-H8-O3-S
Molecular Formula Fragments
- C21-H16-Cl-F3-N4-O3
- C7-H8-O3-S
- COMPONENT