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Substance Name: Lycorine
RN: 476-28-8
UNII: I9Q105R5BU
InChIKey: XGVJWXAYKUHDOO-DANNLKNASA-N

Note

  • From bulbs of LYCORIS & other plants.

Classification Codes

  • Drug / Therapeutic Agent
  • Natural Product

Molecular Formula

  • C16-H17-N-O4

Molecular Weight

  • 287.313
 
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Names and Synonyms

Name of Substance

  • Lycorine

Synonyms

  • 3,3a-Didehydrolycoran-1alpha,2beta-diol
  • Amarylline
  • EINECS 207-503-6
  • Galanthidine
  • Licorine
  • Lycorine
  • Narcissine
  • NSC 401360
  • UNII-I9Q105R5BU

Systematic Names

  • Galanthan-1,2-diol, 3,12-didehydro-9,10-(methylenebis(oxy))-, (1-alpha,2-beta)- (9CI)
  • Lycoran-1-alpha,2-beta-diol, 3,3-alpha-didehydro-
  • Lycoran-1alpha,2beta-diol, 3,3a-didehydro- (8CI)
  • Lycorine

Registry Numbers

CAS Registry Number

  • 476-28-8

FDA UNII

  • I9Q105R5BU

System Generated Number

  • 0000476288

Structure Descriptors

InChI

1S/C16H17NO4/c18-11-3-8-1-2-17-6-9-4-12-13(21-7-20-12)5-10(9)14(15(8)17)16(11)19/h3-5,11,14-16,18-19H,1-2,6-7H2/t11-,14-,15+,16+/m0/s1

InChIKey

XGVJWXAYKUHDOO-DANNLKNASA-N

Smiles

c12[C@H]3[C@@H]4[N@@](Cc1cc1c(c2)OCO1)CCC4=C[C@@H]([C@H]3O)O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 oral 10700mg/kg (10700mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: REGIDITY

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 56(1), Pg. 23S, 1960.
mouse LD50 subcutaneous 145mg/kg (145mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: REGIDITY

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 56(1), Pg. 23S, 1960.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 280 deg C   EXP
log P (octanol-water) 0.930 (none)   EST
Atmospheric OH Rate Constant 2.03E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.