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Substance Name: Colchicoside
RN: 477-29-2
UNII: DYD0I854K7
InChIKey: UXAFRQPVHYZDED-ZZEDUEFDSA-N

Note

  • From colchcium seeds.

Classification Code

  • Drug / Therapeutic Agent

Molecular Formula

  • C27-H33-N-O11

Molecular Weight

  • 547.5537
 
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Names and Synonyms

Name of Substance

  • Colchicoside

Synonyms

  • 3-Demethylcolchicine glucoside
  • 4-17-00-03428 (Beilstein Handbook Reference)
  • BRN 0072204
  • EC 207-513-0
  • EINECS 207-513-0
  • NSC 32992
  • NSC 624672
  • UNII-DYD0I854K7

Systematic Name

  • Colchicoside

Registry Numbers

CAS Registry Number

  • 477-29-2

FDA UNII

  • DYD0I854K7

System Generated Number

  • 0000477292

Structure Descriptors

InChI

1S/C27H33NO11/c1-12(30)28-16-7-5-13-9-19(38-27-24(34)23(33)22(32)20(11-29)39-27)25(36-3)26(37-4)21(13)14-6-8-18(35-2)17(31)10-15(14)16/h6,8-10,16,20,22-24,27,29,32-34H,5,7,11H2,1-4H3,(H,28,30)/t16-,20+,22+,23-,24+,27+/m0/s1

InChIKey

UXAFRQPVHYZDED-ZZEDUEFDSA-N

Smiles

COC1=CC=C2C(=CC1=O)[C@H](CCc3cc(O[C@@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O)c(OC)c(OC)c23)NC(=O)C

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 280mg/kg (280mg/kg) BEHAVIORAL: EXCITEMENT

BEHAVIORAL: TREMOR

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 109, Pg. 386, 1957.
mouse LD50 intravenous 320mg/kg (320mg/kg) BEHAVIORAL: EXCITEMENT

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: TREMOR
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 94, Pg. 453, 1953.
mouse LD50 oral 84mg/kg (84mg/kg) BEHAVIORAL: EXCITEMENT

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: TREMOR
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 94, Pg. 453, 1953.
rat LDLo intracrebral 75ug/kg (0.075mg/kg) BEHAVIORAL: TREMOR

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: EXCITEMENT
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 109, Pg. 386, 1957.
rat LDLo parenteral 75ug/kg (0.075mg/kg)   Farmaco, Edizione Scientifica. Vol. 15, Pg. 533, 1960.