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Substance Name: Eleutherin
RN: 478-36-4
UNII: 9J86WO1VYK
InChIKey: IAJIIJBMBCZPSW-DTWKUNHWSA-N

Classification Codes

  • Antineoplastic Agents
  • Drug / Therapeutic Agent
  • Enzyme Inhibitors
  • Natural Product
  • Topoisomerase II Inhibitors
  • Topoisomerase Inhibitors

Molecular Formula

  • C16-H16-O4

Molecular Weight

  • 272.298
 
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Names and Synonyms

Name of Substance

  • Eleutherin

Synonyms

  • 3,4-Dihydro-1-beta,3-beta-dimethyl-9-methoxy-1H-naphtho(2,3-c)pyran-5,10-dione
  • 5-18-03-00554 (Beilstein Handbook Reference)
  • BRN 0087122
  • Eleutherin
  • UNII-9J86WO1VYK

Systematic Names

  • 1H-Naphtho(2,3-c)pyran-5,10-dione, 3,4-dihydro-1-beta,3-beta-dimethyl-9-methoxy-
  • 1H-Naphtho(2,3-c)pyran-5,10-dione, 3,4-dihydro-9-methoxy-1,3-dimethyl-, (1R-cis)- (9CI)

Registry Numbers

CAS Registry Number

  • 478-36-4

FDA UNII

  • 9J86WO1VYK

System Generated Number

  • 0000478364

Structure Descriptors

InChI

1S/C16H16O4/c1-8-7-11-13(9(2)20-8)16(18)14-10(15(11)17)5-4-6-12(14)19-3/h4-6,8-9H,7H2,1-3H3/t8-,9+/m0/s1

InChIKey

IAJIIJBMBCZPSW-DTWKUNHWSA-N

Smiles

c12c(C(C=3C[C@H](C)O[C@@H](C3C1=O)C)=O)cccc2OC

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LDLo intraperitoneal 400mg/kg (400mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Journal of Pharmaceutical Sciences. Vol. 64, Pg. 1305, 1975.