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Substance Name: Mecasermin rinfabate [USAN:INN]
RN: 478166-15-3


  • Administration increases circulating leptin concentrations in short prepubertal, small for gestational age children, suggesting that IGF-I and/or IGFBP-3 may stimulate leptin secretion by adipose tissue.
  • An IGF-1-BP3 fusion protein that may be useful in treating growth hormone insensitivity syndrome.

Molecular Formula

  • C1559-H2482-N464-O482-S27

Molecular Weight

  • 28648.5526

Classification Code

  • Antidiabetic
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Names and Synonyms

Name of Substance

  • Mecasermin rinfabate [rDNA origin]
  • Mecasermin rinfabate [USAN:INN]
  • somatoKine


  • Iplex
  • Mecasermin rinfabate
  • rhIGF-I/rhIGFBP-3
  • somatoKine

Systematic Names

  • Complex of recombinant human insulin-like growth factor I (somatomedin C) with recombinant human insulin-like growth factor-binding protein 3
  • Insulin-like growth factor I (human), complex with insulin-like growth factor-binding protein IGFBP-3 (human)

Registry Numbers

CAS Registry Number

  • 478166-15-3


  • NZ8M50KKRG

Other Registry Number

  • 433977-72-1

System Generated Number

  • 0478166153