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Substance Name: Dyphylline [USP]
RN: 479-18-5
UNII: 263T0E9RR9
InChIKey: KSCFJBIXMNOVSH-UHFFFAOYSA-N

Note

  • A THEOPHYLLINE derivative with broncho- and vasodilator properties. It is used in the treatment of asthma, cardiac dyspnea, and bronchitis.

Molecular Formula

  • C10-H14-N4-O4

Molecular Weight

  • 254.2446
 

Classification Codes

  • Anti-Asthmatic Agents
  • Autonomic Agents
  • Bronchodilator
  • Bronchodilator Agents
  • Cardiovascular Agents
  • Drug / Therapeutic Agent
  • Enzyme Inhibitors
  • Peripheral Nervous System Agents
  • Phosphodiesterase Inhibitors
  • Respiratory System Agents
  • Vasodilator Agents

Names and Synonyms

Name of Substance

  • Asthmolysin
  • Diprophylline [INN]
  • Dyphylline
  • Dyphylline [USP]

MeSH Heading

  • Dyphylline

Synonyms

  • (+-)-7-(2,3-Dihydroxypropyl)theophylline
  • (1,2-Dihydroxy-3-propyl)thiophyllin
  • 1,3-Dimethyl-7-(2,3-dihydroxypropyl)xanthine
  • 1H-Purine-2,6-dione, 7-(2,3-dihydroxypropyl)-3,7-dihydro-1,3-dimethyl
  • 1H-Purine-2,6-dione, 7-(2,3-dihydroxypropyl)-3,7-dihydro-1,3-dimethyl-, (+-)-
  • 5-26-14-00070 (Beilstein Handbook Reference)
  • 7-(2,3-Dihydroxypropyl)-1,3-dimethylxanthine
  • 7-(2,3-Dihydroxypropyl)-3,7-dihydro-1,3-dimethyl-1H-purine-2,6-dione
  • 7-(2,3-Dihydroxypropyl)theophylline
  • 7-(2,3-Dioxypropyl)theophylline
  • 7-(beta,gamma-Dihydroxypropyl)theophylline
  • AFI-Phyllin
  • Aristophyllin
  • Asthmolysin
  • Astmamasit
  • Astrophyllin
  • BRN 0284563
  • Circain
  • Circair
  • COR-theophylline
  • Coronal
  • Coronarin
  • Corphyllin
  • Dihydroxypropyl theophylline
  • Dihydroxypropyl theopylin (german)
  • Dilor
  • Dilor-400
  • Diphyllin
  • Diphyllin (VAN)
  • Diphylline
  • Diprofilina
  • Diprofilina [INN-Spanish]
  • Diprofillin
  • Diprofillina
  • Diprofillina [DCIT]
  • Diprofilline
  • Diprophyllin
  • Diprophylline
  • Diprophyllinum
  • Diprophyllinum [INN-Latin]
  • Dipropylline
  • Droxine
  • Dyflex
  • Dyphylline
  • EINECS 207-526-1
  • Glyfyllin
  • Glyphyllin
  • Glyphylline
  • Glyphyllinum
  • Hidroxiteofillina
  • Hiphyllin
  • HSDB 3322
  • Hyphylline
  • Isophyllen
  • Liactemin
  • Lufyllin
  • Neo-vasophylline
  • Neophyl
  • Neophyllin
  • Neophyllin M
  • Neophylline
  • Neostenovasan
  • Neothylline
  • Neotilina
  • Neufil
  • Neutrafil
  • Neutrafillina
  • Neutraphyllin
  • Neutraphylline
  • Neutroxantina
  • NSC 14305
  • Propyphyllin
  • Protheophylline
  • Purifilin
  • Silbephyllin
  • Silbephylline
  • Solufilin
  • Solufyllin
  • Soluphyllin
  • Synthophylline
  • Tefilan
  • Teofen
  • Tesfen
  • Theal
  • Theal ampules
  • Thefylan
  • Theophylline, 7-(2,3-dihydroxypropyl)-
  • UNII-263T0E9RR9

Systematic Names

  • 1H-Purine-2,6-dione, 7-(2,3-dihydroxypropyl)-3,7-dihydro-1,3-dimethyl-
  • Diprophylline
  • Theophylline, 7-(2,3-dihydroxypropyl)-

Mixture Names

  • Dilor G
  • Neothylline-GG

Registry Numbers

CAS Registry Number

  • 479-18-5

FDA UNII

  • 263T0E9RR9

Other Registry Numbers

  • 52756-53-3
  • 68350-70-9

System Generated Number

  • 0000479185

Structure Descriptors

InChI

1S/C10H14N4O4/c1-12-8-7(9(17)13(2)10(12)18)14(5-11-8)3-6(16)4-15/h5-6,15-16H,3-4H2,1-2H3

InChIKey

KSCFJBIXMNOVSH-UHFFFAOYSA-N

Smiles

Cn1c2c(c(=O)n(c1=O)C)n(cn2)CC(CO)O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 195mg/kg (195mg/kg)   Strahlentherapie. Vol. 127, Pg. 245, 1965.
mouse LD50 intravenous 1080mg/kg (1080mg/kg)   Research Progress in Organic-Biological and Medicinal Chemistry. Vol. 2, Pg. 288, 1970.
mouse LD50 oral 1954mg/kg (1954mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 116, Pg. 343, 1956.
mouse LD50 subcutaneous 1052mg/kg (1052mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 6, Pg. 601, 1956.
rat LD oral > 400mg/kg (400mg/kg)   Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 35, Pg. 266, 1946.
rat LD50 intravenous 860mg/kg (860mg/kg)   Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 230, Pg. 194, 1957.
rat LD50 subcutaneous 1253mg/kg (1253mg/kg)   Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 230, Pg. 194, 1957.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 161.5 deg C   EXP
log P (octanol-water) -1.460 (none)   EST
Water Solubility 3.33E+05 mg/L 25 EXP
Atmospheric OH Rate Constant 3.50E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.