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Substance Name: Indirubin
RN: 479-41-4
UNII: V86L8P74GI
InChIKey: CRDNMYFJWFXOCH-BUHFOSPRSA-N

Note

  • A bis-indole used in treatment of chronic granulocytic leukemia.

Molecular Formula

  • C16-H10-N2-O2

Molecular Weight

  • 262.267
 

Classification Codes

  • Antibiotics, Antineoplastic
  • Antineoplastic Agents
  • Coloring Agents
  • Drug / Therapeutic Agent
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Names and Synonyms

Name of Substance

  • Indirubin

Synonyms

  • 5-24-08-00507 (Beilstein Handbook Reference)
  • BRN 0088279
  • C.I. 73200
  • Couroupitine B
  • Indigo Red
  • Indigopurpurin
  • Indirubin
  • NSC 105327
  • UNII-V86L8P74GI

Systematic Names

  • (delta(sup 2,3')-Biindoline)-2',3-dione
  • (delta2,3'-Biindoline)-2',3-dione (8CI)
  • 2H-Indol-2-one, 3-(1,3-dihydro-3-oxo-2H-indol-2-ylidene)-1,3-dihydro- (9CI)

Registry Numbers

CAS Registry Number

  • 479-41-4

FDA UNII

  • V86L8P74GI

System Generated Number

  • 0000479414

Structure Descriptors

InChI

1S/C16H10N2O2/c19-15-10-6-2-4-8-12(10)17-14(15)13-9-5-1-3-7-11(9)18-16(13)20/h1-8,17H,(H,18,20)/b14-13+

InChIKey

CRDNMYFJWFXOCH-BUHFOSPRSA-N

Smiles

C1(=C2/Nc3ccccc3C2=O)\c2c(cccc2)NC1=O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 1100mg/kg (1100mg/kg)   Drugs of the Future. Vol. 9, Pg. 266, 1984.
mouse LDLo oral 10gm/kg (10000mg/kg)   Zhongcaoyao. Chinese Traditional and Herbal Medicine. Vol. 13, Pg. 24, 1982.