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Substance Name: Propyphenazone [INN:BAN:DCF]
RN: 479-92-5
UNII: OED8FV75PY
InChIKey: PXWLVJLKJGVOKE-UHFFFAOYSA-N

Classification Codes

  • Analgesics
  • Analgesics, Non-Narcotic
  • Anti-Inflammatory Agents
  • Anti-Inflammatory Agents, Non-Steroidal
  • Antirheumatic Agents
  • Drug / Therapeutic Agent
  • Peripheral Nervous System Agents
  • Sensory System Agents

Molecular Formula

  • C14-H18-N2-O

Molecular Weight

  • 230.3092
 
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Names and Synonyms

Name of Substance

  • Propyphenazone
  • Propyphenazone [INN:BAN:DCF]

Synonyms

  • 1-Phenyl-2,3-dimethyl-4-isopropyl-3-pyrazolin-5-one
  • 1-Phenyl-2,3-dimethyl-4-isopropylpyrazol-5-one
  • 2,3-Dimethyl-4-isopropyl-1-phenyl-3H-pyrazolin-5-one
  • 3-Pyrazolin-5-one, 2,3-dimethyl-4-isopropyl-1-phenyl-
  • 3-Pyrazolin-5-one, 4-isopropyl-2,3-dimethyl-1-phenyl-
  • 4-Isopropyl-2,3-dimethyl-1-phenyl-3-pyrazolin-5-one
  • 4-Isopropylantipyrine
  • 5-24-01-00408 (Beilstein Handbook Reference)
  • 5-Pyrazolone, 1-phenyl-2,3-dimethyl-4-isopropyl-
  • BRN 0204533
  • CCRIS 6716
  • EINECS 207-539-2
  • Isopropylantipyrin
  • Isopropylantipyrine
  • Isopropylantipyrinum
  • Isopropylphenazone
  • Isopropyrine
  • Larodon
  • Propifenazona
  • Propifenazona [INN-Spanish]
  • Propifenazone
  • Propifenazone [DCIT]
  • Propyphenazone
  • Propyphenazonum
  • Propyphenazonum [INN-Latin]
  • UNII-OED8FV75PY

Systematic Names

  • 3H-Pyrazol-3-one, 1,2-dihydro-1,5-dimethyl-4-(1-methylethyl)-2-phenyl-
  • 4-Isopropyl-2,3-dimethyl-1-phenyl-3-pyrazolin-5-one
  • Antipyrine, 4-isopropyl-
  • Isopropylantipyrine
  • Propyphenazone

Registry Numbers

CAS Registry Number

  • 479-92-5

FDA UNII

  • OED8FV75PY

Other Registry Numbers

  • 12542-35-7
  • 128065-64-5
  • 88205-06-5

System Generated Number

  • 0000479925

Structure Descriptors

InChI

1S/C14H18N2O/c1-10(2)13-11(3)15(4)16(14(13)17)12-8-6-5-7-9-12/h5-10H,1-4H3

InChIKey

PXWLVJLKJGVOKE-UHFFFAOYSA-N

Smiles

Cc1c(c(=O)n(n1C)c2ccccc2)C(C)C

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
cat LDLo oral 150mg/kg (150mg/kg) BEHAVIORAL: EXCITEMENT

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Journal of Pharmacology and Experimental Therapeutics. Vol. 61, Pg. 205, 1937.
guinea pig LD50 oral 1050mg/kg (1050mg/kg)   Schweizerische Medizinische Wochenschrift. Vol. 84, Pg. 351, 1954.
mouse LD50 intraperitoneal 295mg/kg (295mg/kg)   Archives Internationales de Pharmacodynamie et de Therapie. Vol. 122, Pg. 434, 1959.
mouse LD50 oral 960mg/kg (960mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 9, Pg. 401, 1959.
rabbit LDLo oral 500mg/kg (500mg/kg) BEHAVIORAL: EXCITEMENT

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Journal of Pharmacology and Experimental Therapeutics. Vol. 61, Pg. 205, 1937.
rat LD50 oral 860mg/kg (860mg/kg)   Yakugaku Zasshi. Journal of Pharmacy. Vol. 97, Pg. 601, 1977.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 103 deg C   EXP
log P (octanol-water) 1.94 (none)   EXP
Water Solubility 3.00E+06 mg/L 15 EXP
Vapor Pressure 5.20E-06 mm Hg 25 EST
Henry's Law Constant 1.84E-09 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 3.92E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.