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Substance Name: Platyphylline
RN: 480-78-4
UNII: A91172AJBY
InChIKey: BTHCJHQOYFUIMG-REYNEDSXSA-N

Note

  • From Senecio platyphyllus.

Molecular Formula

  • C18-H27-N-O5

Molecular Weight

  • 337.413
 

Classification Codes

  • Drug / Therapeutic Agent
  • Mutation Data
  • Natural Product
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Names and Synonyms

Name of Substance

  • Platyphylline

Synonyms

  • (1-alpha)-1,2-Dihydro-12-hydroxysenecionan-11,16-dione
  • EINECS 207-558-6
  • Platiphillin
  • Platiphyllin
  • Platyphylline
  • Senecionan-11,16-dione, 1,2-dihydro-12-hydroxy-, (1-alpha)-
  • UNII-A91172AJBY

Systematic Name

  • Platyphylline

Registry Numbers

CAS Registry Number

  • 480-78-4

FDA UNII

  • A91172AJBY

Related Registry Number

  • 66641-38-1 (hydrochloride)

System Generated Number

  • 0000480784

Structure Descriptors

InChI

1S/C18H27NO5/c1-4-12-9-11(2)18(3,22)17(21)23-10-13-5-7-19-8-6-14(15(13)19)24-16(12)20/h4,11,13-15,22H,5-10H2,1-3H3/b12-4-/t11-,13-,14-,15-,18-/m1/s1

InChIKey

BTHCJHQOYFUIMG-REYNEDSXSA-N

Smiles

C1[N@@]2CC[C@H]3OC(C(\C[C@H]([C@@](C(OC[C@@H](C1)[C@@H]23)=O)(C)O)C)=C\C)=O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 577mg/kg (577mg/kg) BEHAVIORAL: EXCITEMENT

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Toksikologicheskii Vestnik. Vol. (1), Pg. 34, 1997.
mouse LD50 intravenous 105mg/kg (105mg/kg) LIVER: "HEPATITIS (HEPATOCELLULAR NECROSIS), DIFFUSE"

LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA

BLOOD: "LYMPHOMA, INCLUDING HODGKIN'S DISEASE"
Research Today. Vol. 5, Pg. 53, 1949.
mouse LD50 oral 2573mg/kg (2573mg/kg) BEHAVIORAL: EXCITEMENT

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Toksikologicheskii Vestnik. Vol. (1), Pg. 34, 1997.
rat LD50 intraperitoneal 252mg/kg (252mg/kg)   Australian Journal of Experimental Biology and Medical Science. Vol. 46, Pg. 493, 1968.
rat LD50 intravenous 60mg/kg (60mg/kg) BLOOD: "LYMPHOMA, INCLUDING HODGKIN'S DISEASE"

LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA

LIVER: "HEPATITIS (HEPATOCELLULAR NECROSIS), DIFFUSE"
Research Today. Vol. 5, Pg. 53, 1949.
rat LD50 oral 3100mg/kg (3100mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: EXCITEMENT
Toksikologicheskii Vestnik. Vol. (1), Pg. 34, 1997.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 129 deg C   EXP
log P (octanol-water) 1.140 (none)   EST
Atmospheric OH Rate Constant 7.94E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.