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Substance Name: Cepharanthine [JAN]
RN: 481-49-2
UNII: 7592YJ0J6T
InChIKey: YVPXVXANRNDGTA-WDYNHAJCSA-N

Note

  • Isoquinoline alkaloid from tubers of Stephania; stimulates recovery of immunologic function in lymphatic system afte administration of antineoplastic agents or x-irradiation.

Molecular Formula

  • C37-H38-N2-O6

Molecular Weight

  • 606.7152
 

Classification Codes

  • Analgesics
  • Analgesics, Non-Narcotic
  • Anti-Inflammatory Agents
  • Anti-Inflammatory Agents, Non-Steroidal
  • Antineoplastic Agents
  • Antineoplastic Agents, Phytogenic
  • Antirheumatic Agents
  • Drug / Therapeutic Agent
  • Peripheral Nervous System Agents
  • Protective Agents
  • Radiation-Protective Agents
  • Reproductive Effect
  • Sensory System Agents
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Names and Synonyms

Name of Substance

  • Cepharanthine
  • Cepharanthine [JAN]

Synonyms

  • (+)-Cepharanthine
  • 4-27-00-09061 (Beilstein Handbook Reference)
  • 6',12'-Dimethoxy-2,2'-dimethyl-6,7-(methylenebis(oxy))oxyacanthan
  • BRN 0075231
  • CCRIS 6539
  • Cepharanthin
  • Cepharanthine
  • Cepharantin
  • NSC 623442
  • O-Methylcepharanoline
  • UNII-7592YJ0J6T

Systematic Names

  • 6',12'-Dimethoxy-2,2'-dimethyl-6,7-(methylenebis(oxy))oxyacanthan
  • Cepharanthine
  • Oxyacanthan, 6',12'-dimethoxy-2,2'-dimethyl-6,7-(methylenebis(oxy))- (9CI)

Registry Numbers

CAS Registry Number

  • 481-49-2

FDA UNII

  • 7592YJ0J6T

System Generated Number

  • 0000481492

Structure Descriptors

InChI

1S/C37H38N2O6/c1-38-13-11-24-18-31(41-4)33-20-27(24)28(38)16-23-7-10-30(40-3)32(17-23)44-26-8-5-22(6-9-26)15-29-35-25(12-14-39(29)2)19-34-36(37(35)45-33)43-21-42-34/h5-10,17-20,28-29H,11-16,21H2,1-4H3/t28-,29+/m1/s1

InChIKey

YVPXVXANRNDGTA-WDYNHAJCSA-N

Smiles

CN1CCc2cc(c3cc2[C@H]1Cc4ccc(c(c4)Oc5ccc(cc5)C[C@H]6c7c(cc8c(c7O3)OCO8)CCN6C)OC)OC

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 125mg/kg (125mg/kg)   Chemical and Pharmaceutical Bulletin. Vol. 24, Pg. 2413, 1976.
mouse LD50 intravenous 43500ug/kg (43.5mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: CHRONIC PULMONARY EDEMA
Kiso to Rinsho. Clinical Report. Vol. 16, Pg. 3855, 1982.
mouse LD50 oral 1900mg/kg (1900mg/kg) SKIN AND APPENDAGES (SKIN): HAIR: OTHER Kiso to Rinsho. Clinical Report. Vol. 16, Pg. 3855, 1982.
mouse LD50 subcutaneous 100mg/kg (100mg/kg)   Kiso to Rinsho. Clinical Report. Vol. 16, Pg. 3855, 1982.
rat LD50 intraperitoneal > 155mg/kg (155mg/kg)   Drugs in Japan Vol. -, Pg. 648, 1995.
rat LD50 intravenous 57mg/kg (57mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Kiso to Rinsho. Clinical Report. Vol. 16, Pg. 3855, 1982.
rat LD50 oral 2gm/kg (2000mg/kg)   Kiso to Rinsho. Clinical Report. Vol. 16, Pg. 3855, 1982.
rat LD50 oral 2gm/kg (2000mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: CHRONIC PULMONARY EDEMA
Kiso to Rinsho. Clinical Report. Vol. 16, Pg. 3855, 1982.
rat LD50 subcutaneous 100mg/kg (100mg/kg)   Kiso to Rinsho. Clinical Report. Vol. 16, Pg. 3855, 1982.