|
|
Substance Name: Cyperquat [ANSI:ISO]
RN: 48134-75-4
UNII: R865A5OY8J
InChIKey: FMGYKKMPNATWHP-UHFFFAOYSA-N
Note
- An active neurotoxic metabolite of 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE. The compound reduces dopamine levels, inhibits the biosynthesis of catecholamines, depletes cardiac norepinephrine and inactivates tyrosine hydroxylase. These and other toxic effects lead to cessation of oxidative phosphorylation, ATP depletion, and cell death. The compound, which is related to PARAQUAT, has also been used as an herbicide.
Molecular Formula
- C12-H12-N
Molecular Weight
- 170.2338
Classification Codes
- Herbicides
- Pesticides
* denotes mobile formatted website
Links to Resources
NLM Resources (File Locators)
Other Resources (Internet Locators)
Search for this InChIKey on the Web
Names and Synonyms
Results Name
- Cyperquat [ANSI:ISO]
Name of Substance
- 1-Methyl-4-phenylpyridinium
MeSH Heading
- 1-Methyl-4-phenylpyridinium
Synonyms
- 1-Methyl-4-phenylpyridinium
- 5-20-07-00550 (Beilstein Handbook Reference)
- BRN 1618932
- CCRIS 2187
- Cyperquat
- Cyperquat [ANSI]
- MPP+
- N-Methyl-4-phenylpyridine
- N-Methyl-4-phenylpyridinium ion
- Pyridinium, 1-methyl-4-phenyl-
- UNII-R865A5OY8J
Systematic Names
- 1-Methyl-4-phenylpyridinium
- Pyridinium, 1-methyl-4-phenyl-
Registry Numbers
CAS Registry Number
- 48134-75-4
FDA UNII
- R865A5OY8J
Related Registry Number
- 39794-99-5 (chloride)
System Generated Number
- 0048134754
Structure Descriptors
InChI
InChI=1S/C12H12N/c1-13-9-7-12(8-10-13)11-5-3-2-4-6-11/h2-10H,1H3/q+1InChIKey
FMGYKKMPNATWHP-UHFFFAOYSA-NSmiles
C[n+]1ccc(cc1)Toxicity
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
mouse | LD50 | unreported | 27500ug/kg (27.5mg/kg) | "MPTP: A Neurotoxin Producing a Parkinsonian Syndrome, Papers Presented at a Symposium, Bethesda, MD, 1985," Markey, S.P., et al., eds., Orlando, FL, Academic Press, Inc., 1986Vol. -, Pg. 571, 1986. |