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Substance Name: Dihydralazine [INN:BAN]
RN: 484-23-1
UNII: PCU411F5L6
InChIKey: VQKLRVZQQYVIJW-UHFFFAOYSA-N

Note

  • 1,4-Dihydrazinophthalazine. An antihypertensive agent with actions and uses similar to those of HYDRALAZINE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p354)

Molecular Formula

  • C8-H10-N6

Molecular Weight

  • 190.209
 

Classification Codes

  • Antihypertensive Agents
  • Cardiovascular Agents
  • Drug / Therapeutic Agent
  • Human Data
  • Mutation Data
  • Reproductive Effect
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Names and Synonyms

Results Name

  • Dihydralazine [INN:BAN]

Name of Substance

  • Dihydralazine
  • Dihydralazine [INN:BAN]

MeSH Heading

  • Dihydralazine

Synonyms

  • 1,4-Dihydrazinonaphthalazine
  • 1,4-Dihydrazinophthalazine
  • 2,3-Dihydro-1,4-phthalazinedione dihydrazone
  • 5-25-17-00465 (Beilstein Handbook Reference)
  • BRN 0183442
  • C 7441
  • Cassella 532
  • CCRIS 7576
  • Dihidralazina
  • Dihidralazina [INN-Spanish]
  • Dihydralazin
  • Dihydralazine
  • Dihydralazinum
  • Dihydralazinum [INN-Latin]
  • Dihydrallazin
  • Dihydrallazine
  • Dihydrazinophthalazine
  • EINECS 207-605-0
  • Hypopresol
  • Nepresol
  • Nepresolin
  • Nepressol
  • NSC 526654
  • Ophthazin
  • Tonolysin
  • UNII-PCU411F5L6

Systematic Names

  • 1,4-Phthalazinedione, 2,3-dihydro-, dihydrazone (9CI)
  • Dihydralazine
  • Phthalazine, 1,4-dihydrazino-

Registry Numbers

CAS Registry Number

  • 484-23-1

FDA UNII

  • PCU411F5L6

System Generated Number

  • 0000484231

Structure Descriptors

InChI

1S/C8H10N6/c9-11-7-5-3-1-2-4-6(5)8(12-10)14-13-7/h1-4H,9-10H2,(H,11,13)(H,12,14)

InChIKey

VQKLRVZQQYVIJW-UHFFFAOYSA-N

Smiles

c1ccc2c(c1)c(nnc2NN)NN

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
man TDLo oral 38mg/kg/15W-I (38mg/kg) LIVER: "JAUNDICE, OTHER OR UNCLASSIFIED"

SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"
Digestion. Vol. 27, Pg. 47, 1983.
mouse LD50 intraperitoneal 106mg/kg (106mg/kg)   United States Patent Document. Vol. #4376771,
mouse LD50 intravenous 300mg/kg (300mg/kg) VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION European Journal of Medicinal Chemistry--Chimie Therapeutique. Vol. 11, Pg. 107, 1976.

Physical Properties

Physical Property Value Units Temp (deg C) Source
log P (octanol-water) -0.750 (none)   EST
Atmospheric OH Rate Constant 1.31E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.