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Substance Name: Dihydralazine [INN:BAN]
RN: 484-23-1
UNII: PCU411F5L6
InChIKey: VQKLRVZQQYVIJW-UHFFFAOYSA-N
Note
- 1,4-Dihydrazinophthalazine. An antihypertensive agent with actions and uses similar to those of HYDRALAZINE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p354).
Molecular Formula
- C8-H10-N6
Molecular Weight
- 190.209
- All
- Classifications
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- Registry Numbers
- Structure Descriptors
- Toxicity
- Physical Properties
Classification Codes
- Antihypertensive Agents
- Cardiovascular Agents
- Drug / Therapeutic Agent
- Human Data
- Mutation Data
- Reproductive Effect
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Names and Synonyms
Results Name
- Dihydralazine [INN:BAN]
Name of Substance
- Dihydralazine
- Dihydralazine [INN:BAN]
MeSH Heading
- Dihydralazine
Synonyms
- 1,4-Dihydrazinonaphthalazine
- 1,4-Dihydrazinophthalazine
- 2,3-Dihydro-1,4-phthalazinedione dihydrazone
- 5-25-17-00465 (Beilstein Handbook Reference)
- BRN 0183442
- C 7441
- Cassella 532
- CCRIS 7576
- Dihidralazina
- Dihidralazina [INN-Spanish]
- Dihydralazin
- Dihydralazine
- Dihydralazinum
- Dihydralazinum [INN-Latin]
- Dihydrallazin
- Dihydrallazine
- Dihydrazinophthalazine
- EINECS 207-605-0
- Hypopresol
- Nepresol
- Nepresolin
- Nepressol
- NSC 526654
- Ophthazin
- Tonolysin
- UNII-PCU411F5L6
Systematic Names
- 1,4-Phthalazinedione, 2,3-dihydro-, dihydrazone
- Dihydralazine
- Phthalazine, 1,4-dihydrazino-
Registry Numbers
CAS Registry Number
- 484-23-1
FDA UNII
- PCU411F5L6
System Generated Number
- 0000484231
Structure Descriptors
InChI
InChI=1S/C8H10N6/c9-11-7-5-3-1-2-4-6(5)8(12-10)14-13-7/h1-4H,9-10H2,(H,11,13)(H,12,14)InChIKey
VQKLRVZQQYVIJW-UHFFFAOYSA-NSmiles
NNc1nnc(NN)Toxicity
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
man | TDLo | oral | 38mg/kg/15W-I (38mg/kg) | LIVER: "JAUNDICE, OTHER OR UNCLASSIFIED" SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" | Digestion. Vol. 27, Pg. 47, 1983. |
mouse | LD50 | intraperitoneal | 106mg/kg (106mg/kg) | United States Patent Document. Vol. #4376771, | |
mouse | LD50 | intravenous | 300mg/kg (300mg/kg) | VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION | European Journal of Medicinal Chemistry--Chimie Therapeutique. Vol. 11, Pg. 107, 1976. |
Physical Properties
Physical Property | Value | Units | Temp (deg C) | Source |
---|---|---|---|---|
log P (octanol-water) | -0.750 | (none) | EST | |
Atmospheric OH Rate Constant | 1.31E-10 | cm3/molecule-sec | 25 | EST |
Physical property data is provided to ChemIDplus by SRC, Inc.