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Substance Name: Reticuline
RN: 485-19-8
UNII: X35Z551WT4
InChIKey: BHLYRWXGMIUIHG-HNNXBMFYSA-N

Note

  • Opium alkaloid; dopamine receptor blocker.

Classification Codes

  • Drug / Therapeutic Agent
  • Natural Product

Molecular Formula

  • C19-H23-N-O4

Molecular Weight

  • 329.3937
 
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Names and Synonyms

Results Name

  • Reticuline

Name of Substance

  • Reticline
  • Reticuline

Synonyms

  • 5-21-06-00046 (Beilstein Handbook Reference)
  • BRN 4299976
  • d-Reticuline
  • EINECS 207-611-3
  • L-(+)-Reticuline
  • Reticulin
  • Reticuline
  • S-(+)-Reticuline
  • UNII-X35Z551WT4

Systematic Names

  • (S)-1,2,3,4-Tetrahydro-1-((3-hydroxy-4-methoxyphenyl)methyl)-6-methoxy-2-methylisoquinolin-7-ol
  • 7-Isoquinolinol, 1,2,3,4-tetrahydro-1-((3-hydroxy-4-methoxyphenyl)methyl)-6-methoxy-2-methyl-,(S)-

Registry Numbers

CAS Registry Number

  • 485-19-8

FDA UNII

  • X35Z551WT4

Other Registry Numbers

  • 3466-53-3
  • 7344-79-8

System Generated Number

  • 0000485198

Structure Descriptors

InChI

1S/C19H23NO4/c1-20-7-6-13-10-19(24-3)17(22)11-14(13)15(20)8-12-4-5-18(23-2)16(21)9-12/h4-5,9-11,15,21-22H,6-8H2,1-3H3/t15-/m0/s1

InChIKey

BHLYRWXGMIUIHG-HNNXBMFYSA-N

Smiles

CN1CCc2cc(c(cc2[C@@H]1Cc3ccc(c(c3)O)OC)O)OC

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 56mg/kg (56mg/kg) SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Journal of Natural Products. Vol. 42, Pg. 399, 1979.
rat LD50 intraperitoneal 216mg/kg (216mg/kg)   Journal of Ethnopharmacology. Vol. 62, Pg. 57, 1998.