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Substance Name: Cinchonidine
RN: 485-71-2
UNII: 1U622LRA8Z
InChIKey: KMPWYEUPVWOPIM-KODHJQJWSA-N
Note
- Has antimalarial activity; diastereoisomer of cinchonine with distinct physiochemical properties.
Classification Codes
- Drug / Therapeutic Agent
- Natural Product
Molecular Formula
- C19-H22-N2-O
Molecular Weight
- 294.3958
- All
- Links to Resources
- Names & Synonyms
- Registry Numbers
- Structure Descriptors
- Toxicity
- Physical Properties
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Names and Synonyms
Name of Substance
- Cinchonidine
Synonyms
- (-)-Cinchonidine
- (8-alpha,9R)-Cinchonan-9-ol
- (8alpha,9R)Cinchonan-9-ol
- (8S,9R)-Cinchonidine
- 2-Quinuclidinemethanol, alpha-4-quinolyl-5-vinyl-
- AI3-15317
- alpha-Quinidine
- Cinchovatine
- EINECS 207-622-3
- NSC 5364
- UNII-1U622LRA8Z
Systematic Names
- Cinchonan-9-ol, (8-alpha,9R)- (9CI)
- Cinchonan-9-ol, (8a alpha,9R)-
- Cinchonan-9-ol, (8alpha,9R)-
- Cinchonidine
Registry Numbers
CAS Registry Number
- 485-71-2
FDA UNII
- 1U622LRA8Z
Other Registry Numbers
- 1195256-80-4
- 1236363-09-9
- 185122-81-0
- 1892629-78-5
- 402846-41-7
- 727732-19-6
- 834885-39-1
- 849150-57-8
- 887770-94-7
- 898814-12-5
- 900786-79-0
- 900786-82-5
- 911480-48-3
- 925701-86-6
System Generated Number
- 0000485712
Structure Descriptors
InChI
InChI=1S/C19H22N2O/c1-2-13-12-21-10-8-14(13)11-18(21)19(22)16-7-9-20-17-6-4-3-5-15(16)17/h2-7,9,13-14,18-19,22H,1,8,10-12H2/t13-,14-,18-,19+/m0/s1InChIKey
KMPWYEUPVWOPIM-KODHJQJWSA-NSmiles
O[C@@H]([C@@H]1C[C@@H]2CCN1C[C@@H]2C=C)Toxicity
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| quail | LD50 | oral | > 316mg/kg (316mg/kg) | Ecotoxicology and Environmental Safety. Vol. 6, Pg. 149, 1982. | |
| rat | LD50 | intraperitoneal | 206mg/kg (206mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) | Acta Pharmacologica et Toxicologica. Vol. 4, Pg. 265, 1948. |
Physical Properties
| Physical Property | Value | Units | Temp (deg C) | Source |
|---|---|---|---|---|
| Melting Point | 210.5 | deg C | EXP | |
| log P (octanol-water) | 2.82 | (none) | EXP | |
| Water Solubility | 200 | mg/L | 25 | EXP |
| Vapor Pressure | 9.04E-10 | mm Hg | 25 | EST |
| Henry's Law Constant | 1.45E-14 | atm-m3/mole | 25 | EST |
| Atmospheric OH Rate Constant | 1.33E-10 | cm3/molecule-sec | 25 | EST |
Physical property data is provided to ChemIDplus by SRC, Inc.