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Substance Name: Triprolidine [INN:BAN]
RN: 486-12-4
UNII: 2L8T9S52QM
InChIKey: CBEQULMOCCWAQT-WOJGMQOQSA-N

Note

  • Histamine H1 antagonist used in ALLERGIC RHINITIS; ASTHMA; and URTICARIA. It is a component of COUGH and COLD medicines. It may cause drowsiness.

Molecular Formula

  • C19-H22-N2

Molecular Weight

  • 278.3968
 

Classification Codes

  • Anti-Allergic Agents
  • Drug / Therapeutic Agent
  • Histamine Agents
  • Histamine Antagonists
  • Histamine H1 Antagonists
  • Human Data
  • Neurotransmitter Agents

Names and Synonyms

Results Name

  • Triprolidine [INN:BAN]

Name of Substance

  • Triprolidine
  • Triprolidine [INN:BAN]

MeSH Heading

  • Triprolidine

Synonyms

  • (E)-2-(1-(4-Methylphenyl)-3-(1-pyrrolidinyl)-1-propenyl)pyridine
  • CCRIS 7212
  • EINECS 207-627-0
  • HSDB 6316
  • NCI-C61450
  • Pyridine, 2-(1-(4-methylphenyl)-3-(1-pyrrolidinyl)-1-propenyl)-, (E)-
  • Pyridine, 2-(3-(1-pyrrolidinyl)-1-p-tolylpropenyl)-, (E)-
  • trans-1-(2-Pyridyl)-3-pyrrolidino-1-p-tolylprop-1-ene
  • trans-1-(4-Methylphenyl)-1-(2-pyridyl)-3-pyrrolidinoprop-1-ene
  • trans-2-(3-(1-Pyrrolidinyl)-1-p-tolylpropenyl)pyridine
  • Tripolidina
  • Tripolidina [INN-Spanish]
  • Triprolidin
  • Triprolidine
  • Triprolidinum
  • Triprolidinum [INN-Latin]
  • UNII-2L8T9S52QM

Systematic Names

  • Pyridine, 2-(1-(4-methylphenyl)-3-(1-pyrrolidinyl)-1-propenyl)-, (E)-
  • Triprolidine

Superlist Name

  • Triprolidine

Registry Numbers

CAS Registry Number

  • 486-12-4

FDA UNII

  • 2L8T9S52QM

Related Registry Numbers

  • 550-70-9 (mono-hydrochloride)
  • 6138-79-0 (mono-hydrochloride, mono-hydrate)

System Generated Number

  • 0000486124

Structure Descriptors

InChI

1S/C19H22N2/c1-16-7-9-17(10-8-16)18(19-6-2-3-12-20-19)11-15-21-13-4-5-14-21/h2-3,6-12H,4-5,13-15H2,1H3/b18-11+

InChIKey

CBEQULMOCCWAQT-WOJGMQOQSA-N

Smiles

Cc1ccc(cc1)/C(=C\CN2CCCC2)/c3ccccn3

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
human TDLo oral 143ug/kg (0.143mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: CHANGES IN PSYCHOPHYSIOLOGICAL TESTS

BEHAVIORAL: ALTERATION OF OPERANT CONDITIONING
European Journal of Clinical Pharmacology. Vol. 47, Pg. 331, 1994.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 60 deg C   EXP
log P (octanol-water) 3.92 (none)   EXP
Water Solubility 74.9 mg/L 25 EST
Vapor Pressure 8.74E-07 mm Hg 25 EST
Henry's Law Constant 1.08E-10 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 1.82E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.