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Substance Name: Mitobronitol [INN:BAN:DCF:JAN]
RN: 488-41-5
UNII: 5UP30YED7N
InChIKey: VFKZTMPDYBFSTM-KVTDHHQDSA-N

Note

  • Brominated analog of MANNITOL which is an antineoplastic agent appearing to act as an alkylating agent.

Molecular Formula

  • C6-H12-Br2-O4

Molecular Weight

  • 307.9648
 

Classification Codes

  • Alkylating Agents
  • Antineoplastic Agents
  • Antineoplastic Agents, Alkylating
  • Drug / Therapeutic Agent
  • Mutation Data
  • Noxae
  • Reproductive Effect
  • Tumor Data
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Names and Synonyms

Name of Substance

  • Mitobronitol
  • Mitobronitol [INN:BAN:DCF:JAN]

MeSH Heading

  • Mitobronitol

Synonyms

  • 1,6-Dibrom-1,6-didesoxy-D-mannit
  • 1,6-Dibrom-1,6-didesoxy-D-mannit [German]
  • 1,6-Dibromo-1,6-D-didesoxymannitol
  • 1,6-Dibromo-1,6-dideoxy-D-mannitol
  • 1,6-Dibromo-1,6-dideoxymannitol
  • 1,6-Dibromo-D-mannitol
  • 1,6-Dibromomannitol
  • 1,6-Dideoy-1,6-dibromo-D-mannitol
  • 3-01-00-02373 (Beilstein Handbook Reference)
  • AI3-52331
  • BRN 1721919
  • CCRIS 2750
  • DBM
  • Dibromannit
  • Dibromannitol
  • Dibromomannitol
  • EINECS 207-676-8
  • Mielobromol
  • Mitobronitol
  • Mitobronitolum
  • Mitobronitolum [INN-Latin]
  • Myebrol
  • Myelobromol
  • NCI-C04762
  • NSC-94100
  • R 54
  • UNII-5UP30YED7N

Systematic Names

  • 1,6-Dibromo-1,6-dideoxy-D-mannitol
  • D-Mannitol, 1,6-dibromo-1,6-dideoxy-
  • Mannitol, 1,6-dibromo-1,6-dideoxy-, D-
  • Mitobronitol

Registry Numbers

CAS Registry Number

  • 488-41-5

FDA UNII

  • 5UP30YED7N

System Generated Number

  • 0000488415

Structure Descriptors

InChI

1S/C6H12Br2O4/c7-1-3(9)5(11)6(12)4(10)2-8/h3-6,9-12H,1-2H2/t3-,4-,5-,6-/m1/s1

InChIKey

VFKZTMPDYBFSTM-KVTDHHQDSA-N

Smiles

O[C@@H]([C@@H]([C@@H](CBr)O)O)[C@@H](CBr)O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 900mg/kg (900mg/kg) SKIN AND APPENDAGES (SKIN): HAIR: OTHER

BEHAVIORAL: ATAXIA

BEHAVIORAL: TREMOR
Oyo Yakuri. Pharmacometrics. Vol. 6, Pg. 831, 1972.
mouse LD50 intravenous 2200mg/kg (2200mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 8, Pg. 680, 1977.
mouse LD50 oral 1380mg/kg (1380mg/kg) BEHAVIORAL: TREMOR

SKIN AND APPENDAGES (SKIN): HAIR: OTHER

BEHAVIORAL: ATAXIA
Oyo Yakuri. Pharmacometrics. Vol. 6, Pg. 831, 1972.
mouse LD50 subcutaneous 2200mg/kg (2200mg/kg) BEHAVIORAL: TREMOR

SKIN AND APPENDAGES (SKIN): HAIR: OTHER

BEHAVIORAL: ATAXIA
Oyo Yakuri. Pharmacometrics. Vol. 6, Pg. 831, 1972.
rabbit LD50 oral 1080mg/kg (1080mg/kg)   Oyo Yakuri. Pharmacometrics. Vol. 6, Pg. 831, 1972.
rat LD50 intraperitoneal 900mg/kg (900mg/kg) BLOOD: NORMOCYTIC ANEMIA

BLOOD: THROMBOCYTOPENIA
European Journal of Cancer. Vol. 4, Pg. 617, 1968.
rat LD50 intravenous 1370mg/kg (1370mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 8, Pg. 680, 1977.
rat LD50 oral 1500mg/kg (1500mg/kg) GASTROINTESTINAL: OTHER CHANGES

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

BLOOD: NORMOCYTIC ANEMIA
Oyo Yakuri. Pharmacometrics. Vol. 6, Pg. 831, 1972.
rat LD50 subcutaneous 1240mg/kg (1240mg/kg) GASTROINTESTINAL: OTHER CHANGES

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

BLOOD: NORMOCYTIC ANEMIA
Oyo Yakuri. Pharmacometrics. Vol. 6, Pg. 831, 1972.

Physical Properties

Physical Property Value Units Temp (deg C) Source
log P (octanol-water) -0.24 (none)   EXP
Water Solubility 1.95E+04 mg/L 25 EST
Vapor Pressure 1.54E-08 mm Hg 25 EST
Henry's Law Constant 7.21E-12 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 2.94E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.