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Substance Name: Vinburnine [INN]
RN: 4880-88-0
UNII: G54D0HMY25
InChIKey: WYJAPUKIYAZSEM-MOPGFXCFSA-N

Classification Code

  • Drug / Therapeutic Agent

Molecular Formula

  • C19-H22-N2-O

Molecular Weight

  • 294.3958
 
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Names and Synonyms

Name of Substance

  • Eburnamonine (-)-form
  • Vinburnine [INN]

Synonyms

  • (-)-Eburnamonina
  • (-)-Eburnamonina [Spanish]
  • (-)-Eburnamonine
  • (3-alpha,16-alpha)-Eburnamin-14(15H)-one
  • 3-alpha,16-alpha-Eburnamonine
  • CH 846
  • CH-846
  • cis-Vincamone
  • Eburnal
  • Eburnal ritardo
  • EINECS 225-490-5
  • l-Eburnamonine
  • NSC 322920
  • UNII-G54D0HMY25
  • Vinburnina
  • Vinburnina [INN-Spanish]
  • Vinburnine
  • Vinburninum
  • Vinburninum [INN-Latin]
  • Vincamona
  • Vincamona [Spanish]

Systematic Names

  • (3alpha,16alpha)-Eburnamenin-14(15H)-one
  • 3alpha,16alpha-Eburnamonine
  • Eburnamin-14(15H)-one, (3-alpha,16-alpha)- (9CI)
  • Vincamone

Registry Numbers

CAS Registry Number

  • 4880-88-0

FDA UNII

  • G54D0HMY25

Other Registry Numbers

  • 13090-13-6
  • 412037-03-7

System Generated Number

  • 0004880880

Structure Descriptors

InChI

1S/C19H22N2O/c1-2-19-9-5-10-20-11-8-14-13-6-3-4-7-15(13)21(16(22)12-19)17(14)18(19)20/h3-4,6-7,18H,2,5,8-12H2,1H3/t18-,19+/m1/s1

InChIKey

WYJAPUKIYAZSEM-MOPGFXCFSA-N

Smiles

CC[C@@]12CCCN3[C@@H]1c4c(c5ccccc5n4C(=O)C2)CC3

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 265mg/kg (265mg/kg) GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE
Medicamentos de Actualidad. Vol. 14, Pg. 160, 1978.
mouse LD50 intravenous 28mg/kg (28mg/kg) GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE
Medicamentos de Actualidad. Vol. 14, Pg. 160, 1978.
mouse LD50 oral 3gm/kg (3000mg/kg)   United States Patent Document. Vol. #3852453,