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Substance Name: Amiphenazole [INN:BAN]
RN: 490-55-1
UNII: 7ZJ8PWY0XD
InChIKey: UPOYFZYFGWBUKL-UHFFFAOYSA-N

Note

  • Used as a respiratory tonic, morphine antagonist, & antidote in barbiturate poisoning.

Classification Codes

  • Drug / Therapeutic Agent
  • Respiratory System Agents

Molecular Formula

  • C9-H9-N3-S

Molecular Weight

  • 191.257
 
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Names and Synonyms

Name of Substance

  • Amiphenazole
  • Amiphenazole [INN:BAN]

Synonyms

  • 2,4-Diamino-5-phenylthiazole
  • 2,4-Thiazolediamine, 5-phenyl-
  • 4-27-00-05139 (Beilstein Handbook Reference)
  • 5-Phenyl-2,4-thiazolediamine
  • Amifenazol
  • Amifenazol [INN-Spanish]
  • Amiphenazol
  • Amiphenazol [INN-French]
  • Amiphenazole
  • Amiphenazolum
  • Amiphenazolum [INN-Latin]
  • BRN 0157088
  • Daftazol
  • DAPT
  • Daptazile
  • Daptazole
  • DHA-245
  • Dizol
  • EINECS 207-713-8
  • Fenamizol
  • Phenamizol
  • Phenamizole
  • UNII-7ZJ8PWY0XD

Systematic Names

  • 2,4-Diamino-5-phenylthiazole
  • Amiphenazole
  • Thiazole, 2,4-diamino-5-phenyl-

Registry Numbers

CAS Registry Number

  • 490-55-1

FDA UNII

  • 7ZJ8PWY0XD

Related Registry Numbers

  • 6020-54-8 (mono-hydrobromide)
  • 942-31-4 (mono-hydrochloride)

System Generated Number

  • 0000490551

Structure Descriptors

InChI

1S/C9H9N3S/c10-8-7(13-9(11)12-8)6-4-2-1-3-5-6/h1-5H,10H2,(H2,11,12)

InChIKey

UPOYFZYFGWBUKL-UHFFFAOYSA-N

Smiles

c1(c2ccccc2)sc(N)nc1N

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 290mg/kg (290mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY OBSTRUCTION
Pharmaceutical Chemistry Journal Vol. 7, Pg. 489, 1973.
mouse LD50 oral 400mg/kg (400mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 23, Pg. 1125, 1973.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 163.5 dec deg C   EXP
log P (octanol-water) 1.670 (none)   EST
Atmospheric OH Rate Constant 4.79E-12 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.