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Substance Name: Hydroxytetracaine [INN:BAN:DCF]
RN: 490-98-2
UNII: 8A96H4311N
InChIKey: DHCUQNSUUYMFGX-UHFFFAOYSA-N

Classification Code

  • Drug / Therapeutic Agent

Molecular Formula

  • C15-H24-N2-O3

Molecular Weight

  • 280.366
 
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Names and Synonyms

Name of Substance

  • Hydroxytetracaine [INN:BAN:DCF]

Synonyms

  • 2-(Dimethylamino)ethyl-4-(butylamino)salicylate
  • 4-14-00-02001 (Beilstein Handbook Reference)
  • 4-n-Butylamino-salicylsaeure-dimethylaminoaethylester
  • 4-n-Butylamino-salicylsaeure-dimethylaminoaethylester [German]
  • BRN 2125583
  • Hidroxitetracaina
  • Hidroxitetracaina [INN-Spanish]
  • Hydroxamethocaine
  • Hydroxytetracaine
  • Hydroxytetracainum
  • Hydroxytetracainum [INN-Latin]
  • Idrossitetracaina
  • Idrossitetracaina [DCIT]
  • Oxitetracainum
  • Oxypentocain
  • Rhenocain
  • Salicacaine
  • Salicain
  • Salicaine (anesthetic)
  • UNII-8A96H4311N
  • WIN 3546

Systematic Names

  • 2-Dimethylaminoethyl 4-butylaminosalicylate
  • 4-(Butylamino)-2-hydroxy-benzoic acid, 2-(dimethylino)ethyl ester (9CI)
  • Salicylic acid, p-(butylamino)-, 2-(dimethylamino)ethyl ester

Registry Numbers

CAS Registry Number

  • 490-98-2

FDA UNII

  • 8A96H4311N

System Generated Number

  • 0000490982

Structure Descriptors

InChI

1S/C15H24N2O3/c1-4-5-8-16-12-6-7-13(14(18)11-12)15(19)20-10-9-17(2)3/h6-7,11,16,18H,4-5,8-10H2,1-3H3

InChIKey

DHCUQNSUUYMFGX-UHFFFAOYSA-N

Smiles

c1(C(=O)OCCN(C)C)c(cc(NCCCC)cc1)O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 100mg/kg (100mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 2, Pg. 112, 1952.
mouse LD50 intravenous 22mg/kg (22mg/kg) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Journal of Pharmacology and Experimental Therapeutics. Vol. 104, Pg. 40, 1952.
mouse LD50 subcutaneous 115mg/kg (115mg/kg)   Klinische Wochenscrift. Vol. 31, Pg. 97, 1953.
rat LD50 intraperitoneal 90mg/kg (90mg/kg)   Klinische Wochenscrift. Vol. 31, Pg. 97, 1953.
rat LD50 intratracheal 8mg/kg (8mg/kg)   Klinische Wochenscrift. Vol. 31, Pg. 97, 1953.
rat LD50 intravenous 12200ug/kg (12.2mg/kg)   Klinische Wochenscrift. Vol. 31, Pg. 97, 1953.