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Substance Name: Mersalyl [INN:DCF]
RN: 492-18-2
UNII: 5X1IO031V8
InChIKey: WWKZBHGJCDECFG-UHFFFAOYSA-L

Note

  • A toxic thiol mercury salt formerly used as a diuretic. It inhibits various biochemical functions, especially in mitochondria, and is used to study those functions.

Molecular Formula

  • C13-H16-Hg-N-O6.Na

Molecular Weight

  • 505.8504
 

Classification Codes

  • Enzyme Inhibitors
  • Organometallic
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Names and Synonyms

Name of Substance

  • Mersalyl
  • Mersalyl [INN:DCF]

MeSH Heading

  • Mersalyl

Synonyms

  • (3-((2-(Carboxymethoxy)benzoyl)amino)-2-methoxypropyl)hydroxymercury monosodium salt
  • Acetic acid, (o-((3-(hydroxymercuri)-2-methoxypropyl)carbamoyl)phenoxy)-, monosodium salt
  • Diursal
  • EINECS 207-748-9
  • Igrosin
  • Mercuramide
  • Mercurital
  • Mercury, (3-(0-(carboxymethoxy)benzamido)-2-methoxypropyl)hydroxy-, monosodium salt
  • Mercusal
  • Mersalil
  • Mersalil [INN-Spanish]
  • Mersalil [Italian]
  • Mersalile
  • Mersalile [DCIT]
  • Mersalyl
  • Mersalyl acid sodium salt
  • Mersalylum
  • Mersalylum [INN-Latin]
  • N-(gamma-Hydroxymercuri-beta-methoxypropyl)salicylamide-O-acetic acid sodium salt
  • o-((3-Hydroxymercuri-2-methoxypropyl)carbamoyl)phenoxyacetic acid monosodium salt
  • Salurin
  • Salyrgan
  • Sodium mersalyl
  • Sodium O-((3-(hydroxymercuri)-2-methoxypropyl)carbamoyl)phenoxy acetate
  • Sodium salicyl-(gamma-hydroxymercuri-beta-methoxypropyl)amide-O-acetate
  • Sodium salt of o-((3-hydroxymercuri-2-methoxypropyl)carbamoyl)phenoxyacetic acid
  • UNII-5X1IO031V8
  • Uragan

Systematic Names

  • Mercurate(1-), (3-((2-(carboxylatomethoxy)benzoyl)amino)-2-methoxypropyl)hydroxy-, sodium
  • Mercurate(1-), (3-((2-(carboxylatomethoxy)benzoyl-kappaO)amino)-2-methoxypropyl-kappaC)hydroxy-, sodium
  • Mercury, 3-(alpha-carboxy-o-anisamido)-2-methoxypropyl hydroxy-, monosodium salt
  • Mersalyl
  • Sodium salt of o-((3-hydroxymercuri-2-methoxypropyl)carbamoyl)phenoxyacetic acid

Registry Numbers

CAS Registry Number

  • 492-18-2

FDA UNII

  • 5X1IO031V8

Other Registry Number

  • 64615-74-3

Related Registry Number

  • 486-67-9 (mersalyl acid)

System Generated Number

  • 0000492182

Molecular Formulas

Molecular Formula

  • C13-H16-Hg-N-O6.Na

Molecular Formula Fragments

  • C13-H16-Hg-N-O6
  • COMPONENT
  • Na

Structure Descriptors

InChI

1S/C13H16NO5.Hg.Na.H2O/c1-9(18-2)7-14-13(17)10-5-3-4-6-11(10)19-8-12(15)16;;;/h3-6,9H,1,7-8H2,2H3,(H,14,17)(H,15,16);;;1H2/q;2*+1;/p-2

InChIKey

WWKZBHGJCDECFG-UHFFFAOYSA-L

Smiles

COC(CNC(=O)c1ccccc1OCC(=O)[O-])C[Hg]O.[Na+]

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 118mg/kg (118mg/kg)   Journal of Organic Chemistry. Vol. 16, Pg. 1879, 1951.
mouse LD50 intravenous 72600ug/kg (72.6mg/kg)   Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 40, Pg. 249, 1951.
rabbit LD50 intramuscular 24500ug/kg (24.5mg/kg)   Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 40, Pg. 249, 1951.
rabbit LDLo intravenous 7mg/kg (7mg/kg)   Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 152, Pg. 341, 1930.
rat LD50 intramuscular 24mg/kg (24mg/kg)   Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 40, Pg. 249, 1951.
rat LD50 intravenous 17700ug/kg (17.7mg/kg)   Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 40, Pg. 249, 1951.

Physical Properties

Physical Property Value Units Temp (deg C) Source
log P (octanol-water) -1.480 (none)   EST
Water Solubility 5.00E+05 mg/L   EXP
Atmospheric OH Rate Constant 1.22E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.