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Substance Name: Ammodendrine
RN: 494-15-5
UNII: U0X8I482C7
InChIKey: APKLQIQRPUDADG-GFCCVEGCSA-N

Classification Codes

  • Drug / Therapeutic Agent
  • Natural Product

Molecular Formula

  • C12-H20-N2-O

Molecular Weight

  • 208.303
 
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Names and Synonyms

Name of Substance

  • Ammodendrine

Synonyms

  • Ammodendrine
  • Isoammodendrin
  • Isoammodendrine
  • Spherocarpine
  • UNII-U0X8I482C7

Systematic Names

  • Pyridine, 1-acetyl-1,2,3,4-tetrahydro-5-(2-piperidinyl)-, (R)-
  • Pyridine, 1-acetyl-1,2,3,4-tetrahydro-5-(2R)-2-piperidinyl-

Registry Numbers

CAS Registry Number

  • 494-15-5

FDA UNII

  • U0X8I482C7

System Generated Number

  • 0000494155

Structure Descriptors

InChI

1S/C12H20N2O/c1-10(15)14-8-4-5-11(9-14)12-6-2-3-7-13-12/h9,12-13H,2-8H2,1H3/t12-/m1/s1

InChIKey

APKLQIQRPUDADG-GFCCVEGCSA-N

Smiles

CC(=O)N1CCCC(=C1)[C@H]2CCCCN2

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
cat LDLo subcutaneous 200mg/kg (200mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)

BEHAVIORAL: EXCITEMENT
Farmakologiya i Toksikologiya Vol. 9(3), Pg. 12, 1946.
mouse LD50 intravenous 134mg/kg (134mg/kg)   "Toxic Plants and Other Natural Toxicants, Proceedings of the International Symposium on Poisonous Plants, 5th, San Angelo, Texas 1997" Garland, T., and C. Barr eds. New York, CABI Publishing 1998Vol. -, Pg. 345, 1998.
mouse LD50 subcutaneous 385mg/kg (385mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
Farmakologiya i Toksikologiya Vol. 9(3), Pg. 12, 1946.
rabbit LDLo subcutaneous 250mg/kg (250mg/kg) BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) Farmakologiya i Toksikologiya Vol. 9(3), Pg. 12, 1946.