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Substance Name: Fenofibrate [USAN:USP:INN:BAN]
RN: 49562-28-9
UNII: U202363UOS
InChIKey: YMTINGFKWWXKFG-UHFFFAOYSA-N

Note

  • An antilipemic agent which reduces both CHOLESTEROL and TRIGLYCERIDES in the blood.

Molecular Formula

  • C20-H21-Cl-O4

Molecular Weight

  • 360.8349
 

Classification Codes

  • Antihyperlipidemic
  • Antimetabolites
  • Drug / Therapeutic Agent
  • Hypolipidemic Agents
  • Lipid Regulating Agents
  • Reproductive Effect

Names and Synonyms

Name of Substance

  • Fenofibrate
  • Fenofibrate [USAN:USP:INN:BAN]
  • Procetofen

MeSH Heading

  • Fenofibrate

Synonyms

  • 2-(4-(4-Chlorobenzoyl)phenoxy)-2-methylpropanoic acid 1-methylethyl ester
  • Ankebin
  • Antara
  • Antara (micronized)
  • BRN 2062462
  • CCRIS 7282
  • EC 256-376-3
  • EINECS 256-376-3
  • Elasterate
  • Elasterin
  • Fenobrate
  • Fenofibrate
  • Fenofibrate (micronized)
  • Fenofibrato
  • Fenofibrato [INN-Spanish]
  • Fenofibratum
  • Fenofibratum [INN-Latin]
  • Fenogal
  • Fenoglide
  • Fenotard
  • HSDB 7736
  • Isopropyl (4'-(p-chlorobenzoyl)-2-phenoxy-2-methyl)propionate
  • Isopropyl 2-(4-(4-chlorobenzoyl)phenoxy)-2-methylpropionate
  • Isopropyl 2-(p-(p-chlorobenzoyl)phenoxy)-2-methylpropionate
  • LF-178
  • Lipanthyl
  • Lipantil
  • Lipidex
  • Lipidil
  • Lipifen
  • Lipirex
  • Lipoclar
  • Lipofen
  • Lipofene
  • Liposit
  • Lipsin
  • Luxacor
  • Nolipax
  • NSC 281319
  • Procetofen
  • Proctofene
  • Protolipan
  • Secalip
  • Sedufen
  • Tricor
  • Tricor (micronized)
  • Triglide
  • UNII-U202363UOS

Systematic Names

  • Fenofibrate
  • Isopropyl 2-(p-(p-chlorobenzoyl)phenoxy)-2-methylpropionate
  • Propanoic acid, 2-(4-(4-chlorobenzoyl)phenoxy)-2-methyl-, 1-methylethyl ester

Registry Numbers

CAS Registry Number

  • 49562-28-9

FDA UNII

  • U202363UOS

System Generated Number

  • 0049562289

Structure Descriptors

InChI

1S/C20H21ClO4/c1-13(2)24-19(23)20(3,4)25-17-11-7-15(8-12-17)18(22)14-5-9-16(21)10-6-14/h5-13H,1-4H3

InChIKey

YMTINGFKWWXKFG-UHFFFAOYSA-N

Smiles

CC(C)OC(=O)C(C)(C)Oc1ccc(cc1)C(=O)c2ccc(cc2)Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 oral > 4gm/kg (4000mg/kg)   Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 23(Suppl,
hamster LD50 oral > 5gm/kg (5000mg/kg)   American Journal of Medicine. Vol. 83(Suppl,
mouse LD50 oral 1600mg/kg (1600mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 26, Pg. 885, 1976.
rat LD50 oral > 2gm/kg (2000mg/kg) LIVER: OTHER CHANGES Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 23(Suppl,

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 80.5 deg C   EXP
log P (octanol-water) 5.190 (none)   EST
Atmospheric OH Rate Constant 2.52E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.