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Substance Name: Bromisoval [INN]
RN: 496-67-3
UNII: 469GW8R486
InChIKey: CMCCHHWTTBEZNM-UHFFFAOYSA-N

Note

  • A sedative and mild hypnotic with potentially toxic effects.

Molecular Formula

  • C6-H11-Br-N2-O2

Molecular Weight

  • 223.0689
 

Classification Codes

  • Central Nervous System Agents
  • Central Nervous System Depressants
  • Drug / Therapeutic Agent
  • Human Data
  • Hypnotics and Sedatives
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Names and Synonyms

Results Name

  • Bromisoval [INN]

Name of Substance

  • Bromisoval [INN]
  • Bromisovalum
  • Bromisovalum [NF]
  • Bromvalerylurea [JAN]

MeSH Heading

  • Bromisovalum

Synonyms

  • (alpha-Bromoisovaleryl)urea
  • 2-Bromisovalerylmocovina
  • 2-Bromisovalerylmocovina [Czech]
  • 2-Bromo-3-methylbutyrylurea
  • 2-Monobromoisovalerylurea
  • 3-03-00-00123 (Beilstein Handbook Reference)
  • Abroval
  • Alluval
  • alpha-Bromo-beta-dimethylpropanoylurea
  • alpha-Bromoisovaleric acid ureide
  • alpha-Bromoisovaleroylurea
  • Alural
  • BRN 1773255
  • Bromaral
  • Bromcarbamide
  • Bromisoval
  • Bromisovalerylurea
  • Bromisovalum
  • Bromisovalum [INN-Latin]
  • Bromizoval
  • Bromocarbamide
  • Bromoval
  • Bromovalerocarbamide
  • Bromovalerylurea
  • Bromoxil
  • Bromural
  • Bromuvan
  • Bromvalerocarbamidum
  • Bromvalerylurea
  • Bromvaletone
  • Bromvaletonum
  • Bromvalurea
  • Brovalin
  • Brovalurea
  • Brovarin
  • Calmotin
  • Dagrabromyl
  • Dibroluur
  • Dormigene
  • EINECS 207-825-7
  • Isobromyl
  • Monobromoisolvalerylurea
  • N-(Aminocarbonyl)-2-bromo-3-methylbutanamide
  • Pivadorm
  • Pivadorn
  • Somnurol
  • UNII-469GW8R486
  • Upiol
  • Uvaleral

Systematic Names

  • 2-Bromo-3-methylbutyrylurea
  • Bromisoval
  • Butanamide, N-(aminocarbonyl)-2-bromo-3-methyl-
  • Urea, (2-bromo-3-methylbutyryl)-

Registry Numbers

CAS Registry Number

  • 496-67-3

FDA UNII

  • 469GW8R486

Other Registry Numbers

  • 12622-72-9
  • 66101-52-8

System Generated Number

  • 0000496673

Structure Descriptors

InChI

1S/C6H11BrN2O2/c1-3(2)4(7)5(10)9-6(8)11/h3-4H,1-2H3,(H3,8,9,10,11)

InChIKey

CMCCHHWTTBEZNM-UHFFFAOYSA-N

Smiles

CC(C)C(C(=O)NC(=O)N)Br

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
cat LD50 oral 450mg/kg (450mg/kg)   Drugs in Japan Vol. 6, Pg. 738, 1982.
frog LDLo unreported 900mg/kg (900mg/kg)   "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1289, 1935.
guinea pig LDLo rectal 1400mg/kg (1400mg/kg)   Toho Igakkai Zasshi. Journal of Medical Society of Toho University. Vol. 7, Pg. 513, 1960.
human LDLo oral 57mg/kg (57mg/kg)   Toho Igakkai Zasshi. Journal of Medical Society of Toho University. Vol. 7, Pg. 513, 1960.
man TDLo oral 257mg/kg (257mg/kg) BEHAVIORAL: SLEEP

VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES		 Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 34, Pg. 2792, 1992.
man TDLo oral 286mg/kg (286mg/kg) BEHAVIORAL: ATAXIA

BEHAVIORAL: SLEEP

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD		 Rinsho Shinkeigaku. Clinical Neurology. Vol. 20, Pg. 969, 1980.
man TDLo oral 309mg/kg (309mg/kg) BEHAVIORAL: COMA Japanese Journal of Toxicology. Vol. 11, Pg. 275, 1998.
mouse LD50 intraperitoneal 660mg/kg (660mg/kg)   Drugs in Japan Vol. -, Pg. 1213, 1995.
mouse LD50 oral 1340mg/kg (1340mg/kg)   Drugs in Japan Vol. -, Pg. 1213, 1995.
rabbit LDLo unreported 1gm/kg (1000mg/kg)   "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1289, 1935.
rat LD50 oral 1gm/kg (1000mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) Federation Proceedings, Federation of American Societies for Experimental Biology. Vol. 7, Pg. 262, 1948.
women TDLo oral 400mg/kg (400mg/kg) BEHAVIORAL: COMA

GASTROINTESTINAL: NAUSEA OR VOMITING		 British Medical Journal. Vol. 1, Pg. 1238, 1955.
women TDLo oral 600mg/kg (600mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: SLEEP

VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION		 Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 34, Pg. 2792, 1992.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 154 deg C   EXP
log P (octanol-water) 1.14 (none)   EXP
Water Solubility 3520 mg/L 25 EST
Vapor Pressure 5.18E-07 mm Hg 25 EST
Henry's Law Constant 2.91E-11 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 8.85E-12 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.