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Substance Name: Bromisoval [INN]
RN: 496-67-3
UNII: 469GW8R486
InChIKey: CMCCHHWTTBEZNM-UHFFFAOYSA-N
Note
- A sedative and mild hypnotic with potentially toxic effects.
Molecular Formula
- C6-H11-Br-N2-O2
Molecular Weight
- 223.0689
- All
- Classifications
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- Names & Synonyms
- Registry Numbers
- Structure Descriptors
- Toxicity
- Physical Properties
Classification Codes
- Central Nervous System Agents
- Central Nervous System Depressants
- Drug / Therapeutic Agent
- Human Data
- Hypnotics and Sedatives
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Names and Synonyms
Results Name
- Bromisoval [INN]
Name of Substance
- Bromisoval [INN]
- Bromisovalum
- Bromisovalum [NF]
- Bromvalerylurea [JAN]
MeSH Heading
- Bromisovalum
Synonyms
- (alpha-Bromoisovaleryl)urea
- 2-Bromisovalerylmocovina
- 2-Bromisovalerylmocovina [Czech]
- 2-Bromo-3-methylbutyrylurea
- 2-Monobromoisovalerylurea
- 3-03-00-00123 (Beilstein Handbook Reference)
- Abroval
- Alluval
- alpha-Bromo-beta-dimethylpropanoylurea
- alpha-Bromoisovaleric acid ureide
- alpha-Bromoisovaleroylurea
- Alural
- BRN 1773255
- Bromaral
- Bromcarbamide
- Bromisoval
- Bromisovalerylurea
- Bromisovalum
- Bromisovalum [INN-Latin]
- Bromizoval
- Bromocarbamide
- Bromoval
- Bromovalerocarbamide
- Bromovalerylurea
- Bromoxil
- Bromural
- Bromuvan
- Bromvalerocarbamidum
- Bromvalerylurea
- Bromvaletone
- Bromvaletonum
- Bromvalurea
- Brovalin
- Brovalurea
- Brovarin
- Calmotin
- Dagrabromyl
- Dibroluur
- Dormigene
- EINECS 207-825-7
- Isobromyl
- Monobromoisolvalerylurea
- N-(Aminocarbonyl)-2-bromo-3-methylbutanamide
- Pivadorm
- Pivadorn
- Somnurol
- UNII-469GW8R486
- Upiol
- Uvaleral
Systematic Names
- 2-Bromo-3-methylbutyrylurea
- Bromisoval
- Butanamide, N-(aminocarbonyl)-2-bromo-3-methyl-
- Urea, (2-bromo-3-methylbutyryl)-
Registry Numbers
CAS Registry Number
- 496-67-3
FDA UNII
- 469GW8R486
Other Registry Numbers
- 12622-72-9
- 66101-52-8
System Generated Number
- 0000496673
Structure Descriptors
InChI
1S/C6H11BrN2O2/c1-3(2)4(7)5(10)9-6(8)11/h3-4H,1-2H3,(H3,8,9,10,11)InChIKey
CMCCHHWTTBEZNM-UHFFFAOYSA-NSmiles
CC(C)Toxicity
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
cat | LD50 | oral | 450mg/kg (450mg/kg) | Drugs in Japan Vol. 6, Pg. 738, 1982. | |
frog | LDLo | unreported | 900mg/kg (900mg/kg) | "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1289, 1935. | |
guinea pig | LDLo | rectal | 1400mg/kg (1400mg/kg) | Toho Igakkai Zasshi. Journal of Medical Society of Toho University. Vol. 7, Pg. 513, 1960. | |
human | LDLo | oral | 57mg/kg (57mg/kg) | Toho Igakkai Zasshi. Journal of Medical Society of Toho University. Vol. 7, Pg. 513, 1960. | |
man | TDLo | oral | 257mg/kg (257mg/kg) | BEHAVIORAL: SLEEP VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES | Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 34, Pg. 2792, 1992. |
man | TDLo | oral | 286mg/kg (286mg/kg) | BEHAVIORAL: ATAXIA BEHAVIORAL: SLEEP BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Rinsho Shinkeigaku. Clinical Neurology. Vol. 20, Pg. 969, 1980. |
man | TDLo | oral | 309mg/kg (309mg/kg) | BEHAVIORAL: COMA | Japanese Journal of Toxicology. Vol. 11, Pg. 275, 1998. |
mouse | LD50 | intraperitoneal | 660mg/kg (660mg/kg) | Drugs in Japan Vol. -, Pg. 1213, 1995. | |
mouse | LD50 | oral | 1340mg/kg (1340mg/kg) | Drugs in Japan Vol. -, Pg. 1213, 1995. | |
rabbit | LDLo | unreported | 1gm/kg (1000mg/kg) | "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1289, 1935. | |
rat | LD50 | oral | 1gm/kg (1000mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) | Federation Proceedings, Federation of American Societies for Experimental Biology. Vol. 7, Pg. 262, 1948. |
women | TDLo | oral | 400mg/kg (400mg/kg) | BEHAVIORAL: COMA GASTROINTESTINAL: NAUSEA OR VOMITING | British Medical Journal. Vol. 1, Pg. 1238, 1955. |
women | TDLo | oral | 600mg/kg (600mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: SLEEP VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION | Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 34, Pg. 2792, 1992. |
Physical Properties
Physical Property | Value | Units | Temp (deg C) | Source |
---|---|---|---|---|
Melting Point | 154 | deg C | EXP | |
log P (octanol-water) | 1.14 | (none) | EXP | |
Water Solubility | 3520 | mg/L | 25 | EST |
Vapor Pressure | 5.18E-07 | mm Hg | 25 | EST |
Henry's Law Constant | 2.91E-11 | atm-m3/mole | 25 | EST |
Atmospheric OH Rate Constant | 8.85E-12 | cm3/molecule-sec | 25 | EST |
Physical property data is provided to ChemIDplus by SRC, Inc.